DESIGN, DEVELOPMENT AND EVALUATION OF MUCCOADHESIVE PATCHES OF NIFEDIPINE FOR BUCCAL DELIVERY
Journal Title: Asian J of Pharm Sci & Tech - Year 2012, Vol 2, Issue 1
Abstract
ABSTRACT The buccal region offers an attractive route of administration for systemic drug delivery. Nifedipine is a calcium channel blocker and its oral bioavailability is 45-56% because of first pass metabolism. Buccal route of drug delivery provides direct access to the systemic circulation and thus bypasses liver and avoids pre-systemic elimination in the GI tract and liver and a high bioavailability is obtained. FTIR and UV spectroscopic methods revealed that there was no interaction between nifedipine and polymers. Nifedipine patches were prepared using polymers like Chitosan, PVP K 30, PVA, and HPMC. The patches were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, swelling behaviour, tensile strength, and surface pH. In vitro release studies were conducted for nifedipine loaded patches in phosphate buffer (pH, 6.8) solution. Patches exhibited drug release in the range of 86.26 to 98.32% in 90 min. Data of in vitro release from patches were fit to different equations and kinetic models to explain release profiles. Kinetic models used were zero and first-order equations, Higuchi, and Korsmeyer-Peppas models. The selected patches were further studied for temperature dependant stability studies. It was found that the drug loss was less through the patches stored for one month. Key Words: Nifedipine, Buccal patches, in vitro release, Bioadhesive strength.
Authors and Affiliations
Liji Jacob* C. I. Sajeeth, K. Santhi
Keywords
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