Determination of concentration intra-erythrocyte of metformin in type 2 diabetic patients with or without renal impairment : Comparative study of concentrations intra-erythrocytes between two groups of diabetic patients
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 7
Abstract
ABSTRACT : Type 2 diabetes and renal failure are insidious diseases. Worldwide, diabetes is the leading cause of chronic kidney disease. In Morocco, diabetes and kidney disease are two diseases on the rise and represent a real public health problem. The prevalence of diabetes in Morocco reached 9% of people aged over 20 years, 50% remain undiagnosed. Diabetes is the leading cause of chronic kidney disease whose prevalence is 2.9% in Morocco. The pathophysiology of type 2 diabetes appears to be dominated by insulin resistance and a lack of insulin secretion. Its management is based on the management of these two factors diabetogenic by physical activity, lifestyle changes and drug therapy (biguanides, glitazones, sulfonylureas). Metformin (biguanide) discovery in the 1950s is the oral antidiabetic medication, insulin sensitizer most prescribed in the world. In Morocco, it remains the most accessible for free. Its use requires compliance with its various consindications including impaired renal function. Metformin is excreted by the kidney with a clearance 440-450 ml / min. The main risk in renal insufficiency is lactic acidosis (LA) by accumulation or Intoxication with metformin. The intra-erythrocyte concentration of metformin is the best assessment of this accumulation indicator. The use of metformin may be as beneficial in patients with diabetes type 2 insulin-resistant renal impairment. Very few studies have been done on metformin and renal failure, hence the interest of our study in Morocco, Mediterranean region, to identify and study the difference of concentrations of metformin for type 2 diabetic patients with or without renal impairment.
Authors and Affiliations
"Diarra Martin 1 ; Tadmori Az Eddine 1 ; , Abdessadek Mohammed 2 ; El Attari Ahmed 2 ; Khabbal Youssef 2 , ; Khabbal Youssef 2,3 ; Ajdi Farida 1 3 Science team medicines - Medical Center of Biomedical and Translational Research. Faculty of Medicine and Pharmacy, University
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