DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TIANEPTINE IN API AND TABLET DOSAGE FORM
Journal Title: Int J of Pharm Res & Analy - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Tianeptine, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Zorbax C18 (4.6 x 250mm, 5µm) column using a mixture of Water and Methanol (85:15% v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 218nm. The retention time of the Tianeptine was 5.430±0.02min respectively. The method produce linear responses in the concentration range of 10-50 µg/ml of Tianeptine. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. Keywords: Tianeptine, RP-HPLC, Method development, Validation, Tablet Dosage form
Authors and Affiliations
A. Prateep Reddy*, K. Shilpa, A. Ajitha, V. Uma Maheswara Rao
Keywords
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- EP ID EP138716
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