EFFECT OF PROLONGED ADMINISTRATION OF METHANOLIC EXTRACT OF GANODERMA LUCIDUM ON BLOOD GLUCOSE LEVEL IN NORMAL ALBINO RATS
Journal Title: Int J of Pharm Res & Analy - Year 2014, Vol 4, Issue 2
Abstract
The effect of methanolic extract of Ganoderma lucidum on blood glucose level was investigated in normal albino rats by enzymatic oxidation method. Doses of 200 mg/kg, 400 mg/kg and 800 mg/kg were administered to albino rats in groups A, B and C while rats in group D were used as control and administered with water. The extract was orally administered consecutively for 21 days, and two weeks withdrawal period was also monitored. Serum sample was collected from the experimental rats after sacrificing five rats weekly per each group. Pre-treatment, treatment and withdrawal values were analysed and compared to control. Blood glucose level was found to significantly (P<0.05) decrease within the treatment period compared to pre-treatment and control suggesting possible hypoglycemic effect of the methanolic extract of wild Ganoderma lucidum which may be used in the management of disease such as diabetes mellitus.
Authors and Affiliations
Shamaki BU , Ogbe AO , Abdulrahman FI , Sandabe UK
Keywords
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