EFFECT OF PROLONGED ADMINISTRATION OF METHANOLIC EXTRACT OF GANODERMA LUCIDUM ON BLOOD GLUCOSE LEVEL IN NORMAL ALBINO RATS
Journal Title: Int J of Pharm Res & Analy - Year 2014, Vol 4, Issue 2
Abstract
The effect of methanolic extract of Ganoderma lucidum on blood glucose level was investigated in normal albino rats by enzymatic oxidation method. Doses of 200 mg/kg, 400 mg/kg and 800 mg/kg were administered to albino rats in groups A, B and C while rats in group D were used as control and administered with water. The extract was orally administered consecutively for 21 days, and two weeks withdrawal period was also monitored. Serum sample was collected from the experimental rats after sacrificing five rats weekly per each group. Pre-treatment, treatment and withdrawal values were analysed and compared to control. Blood glucose level was found to significantly (P<0.05) decrease within the treatment period compared to pre-treatment and control suggesting possible hypoglycemic effect of the methanolic extract of wild Ganoderma lucidum which may be used in the management of disease such as diabetes mellitus.
Authors and Affiliations
Shamaki BU , Ogbe AO , Abdulrahman FI , Sandabe UK
Keywords
Related Articles
- EP ID EP157991
- DOI -
- Views 119
- Downloads 0
ANALYTICAL TECHNIQUES FOR THE ESTIMATION OFAGOMELATINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW
Agomelatine (N-[2-(7-methoxynaphthalen-1-yl) ethyl] acetamide), its antidepressant efficacy has been verified in the treatment of major depressive disorder (MDD).Agomelatine showed significant benefits over paroxetine du...
RAPID SEPARATION AND ESTIMATION OF LAMIVUDINE AND ZIDOVUDINE IN MARKETED FORMULATIONS USING RP-HPLC METHOD AND ITS VALIDATION
The goal of the present investigation was carried out to develop a validated analytical RP-HPLC method for simultaneous separation and estimation of Lamivudine and Zidovudine for pharmaceutical formulations. The chromat...
X-RAY FLUORESCENCE
X-ray fluorescence (XRF) spectrometry is an elemental analysis technique with broad application in science and industry. XRF is based on the principle that individual atoms, when excited by an external energy source, emi...
DEVELOPMENT OF UV SPECTROSCOPIC METHOD FOR THE DETERMINATION OF GUAIFENESIN IN BULK AND FORMULATION
The present research work discusses the development of UV Spectroscopic method for the estimation of Guaifenesin. Simple, specific, accurate and cost effective spectroscopic method has been developed for the estimation o...
ASSAY METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF PAROXETINE AND CLONAZEPAM BY RP- HPLC
A simple, precise, rapid, specific and accurate reverse phase high performance liquid chromatography method was developed for simultaneous estimation of Paroxetine and Clonazepam in pharmaceutical dosage form. Chromatogr...