DEVELOPMENT OF UV SPECTROSCOPIC METHOD FOR THE DETERMINATION OF GUAIFENESIN IN BULK AND FORMULATION
Journal Title: Int J of Pharm Res & Analy - Year 2015, Vol 5, Issue 2
Abstract
The present research work discusses the development of UV Spectroscopic method for the estimation of Guaifenesin. Simple, specific, accurate and cost effective spectroscopic method has been developed for the estimation of Guaifenesin in bulk as well as formulation. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λmax) was found to be 240nm. The validation was performed as per ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The method shows high sensitivity with linearity in the range of 1-9 μg/ml and shows a linear relationship between the absorbance and concentration with coefficient of correlation 0.9992. The regression of curve was Y = 0.054 + 0.030. The precision of method was found to be good. The percentage recovery was found to be 99.57 ± 0.38. The optimized showed good reproducibility and recovery with RSD < 2%. The proposed method will be suitable for analysis of Guaifenesin in bulk as well as pharmaceutical formulations in quality control purpose. It is thus concluded that the proposed method is new, simple, cost effective, safe, accurate, precise and environmental friendly.
Authors and Affiliations
PUSHPALATHA E , Tejaswini P , Najboon bi M , Vineesha S , Madhuna MD , Anil Kumar T , Raju M
Keywords
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