DEVELOPMENT OF UV SPECTROSCOPIC METHOD FOR THE DETERMINATION OF GUAIFENESIN IN BULK AND FORMULATION
Journal Title: Int J of Pharm Res & Analy - Year 2015, Vol 5, Issue 2
Abstract
The present research work discusses the development of UV Spectroscopic method for the estimation of Guaifenesin. Simple, specific, accurate and cost effective spectroscopic method has been developed for the estimation of Guaifenesin in bulk as well as formulation. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λmax) was found to be 240nm. The validation was performed as per ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The method shows high sensitivity with linearity in the range of 1-9 μg/ml and shows a linear relationship between the absorbance and concentration with coefficient of correlation 0.9992. The regression of curve was Y = 0.054 + 0.030. The precision of method was found to be good. The percentage recovery was found to be 99.57 ± 0.38. The optimized showed good reproducibility and recovery with RSD < 2%. The proposed method will be suitable for analysis of Guaifenesin in bulk as well as pharmaceutical formulations in quality control purpose. It is thus concluded that the proposed method is new, simple, cost effective, safe, accurate, precise and environmental friendly.
Authors and Affiliations
PUSHPALATHA E , Tejaswini P , Najboon bi M , Vineesha S , Madhuna MD , Anil Kumar T , Raju M
Keywords
Related Articles
- EP ID EP95731
- DOI -
- Views 112
- Downloads 0
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE, LAMIVUDINE AND EFAVIRENZ IN BULK AND TABLET DOSAGE FORM
A simple, sensitive, rapid, economic and accurate first order derivative spectrophotometric method has been developed for estimation of Tenofovir disoproxil fumarate (TDF), Lamivudine (LAM) and Efavirenz (EFV) and...
[b]TRACKING BIOACTIVE CONTENT IN BUTANOL EXTRACT OF CITRULLUS COLOCYNTHISL. FRUIT PULP BY GC/MS [/b]
Citrullus colocynthis (L.) a member of Cucurbitaceae family, was collected from the different areas of the Kachchh region. The fruit pulp of Citrullus colocynthis (L.) was subjected to continuous and successive sox...
PHENOTYPIC AND GENOTYPIC CHARACTERIZATION OF FUGA CATTLE BREED BASED ON THE ANALYSIS OF MICROSATELLITES MARKERS
A survey was conducted through questionnaire guided interviews with cattle owners (household survey) in selected districts in Fuga cattle habitats. Five villages were selected according to the clustering of villages wit...
SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF Fe(II) AND Zn(II) IN MULTIVITAMIN SOFT GEL CAPSULE
The present work describes novel spectrophotometric method for the determination of Fe(II) and Zn(II) in multivitamin soft gel formulation. The method is based on formation of coloured complexes of Fe(II) and Zn(II...
DEVELOPMENT AND VALIDATION OF NEW RP-HPLC METHOD FOR CEFTIBUTEN IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
A simple, precise, rapid and accurate reverse phase HPLC method has been developed for the determination of Ceftibuten in bulk and its pharmaceutical dosage form. An enable C18G, 250mmX4.6mm i.d, 5μm particle size...