DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE ESTIMATION OF CEFTAROLINE FOSAMIL IN BULK AND INJECTION FORM
Journal Title: Int J of Preclin & Pharm Res - Year 2012, Vol 2, Issue 2
Abstract
ABSTRACT Two simple, sensitive, specific, spectrophotometric methods have been developed for the determination of ceftaroline fosamil in bulk and Injection forms. The λmax of ceftaroline fosamil was found to be 245.2 nm in distilled water. The zero order UV Spectrophotometric method exhibits high sensitivity, with linearity and obeys beer’s law in the range of 2 – 10 µg/mL. The limit of detection and quantification were found to be 0.231 µg/mL and 0.7019 µg/mL respectively. While area under curve for zero order spectrum of ceftaroline fosamil was measured from 235 – 255 nm which obeys Beer’s law in the concentration range of 2 – 10 µg/mL. These methods were fully validated according to ICH guidelines. The LOD and LOQ were found to be 0.223µg/mL and 0.669 µg/m, respectivelyL. Hence it could be concluded that the proposed methods would be suitable for the analysis of ceftaroline fosamil in bulk and pharmaceutical preparations. Keywords: Ceftaroline fosamil, UV – Spectorphotometric methods, Validation.
Authors and Affiliations
A. Suneetha*, K. China Venkanna, S. Kathirvel
Keywords
Related Articles
- EP ID EP138708
- DOI -
- Views 93
- Downloads 0
AN OVERVIEW ON FLOWCYTOMETRY
ABSTRACT Flowcytometry is a powerful technology mainly used for investigations in cell biology and isolation of individual cells.It is a laser based biophysical analytical technique used mainly for cell sorting,...
ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY: AN INTRODUCTION AND REVIEW
ABSTRACT Ultra Performance Liquid Chromatography (UPLC) is a relatively new technique giving new possibilities in liquid chromatography, especially concerning decrease of time and solvent consumption. UPLC chroma...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF RUFINAMIDE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
ABSTRACT A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Rufinamide, in its pure form as well as in tablet dosage form. Chromatography was...
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE, LAMIVUDINE AND EFAVIRENZ IN BULK AND TABLET DOSAGE FORM
ABSTRACT A simple, sensitive, rapid, economic and accurate first order derivative spectrophotometric method has been developed for estimation of Tenofovir disoproxil fumarate (TDF), Lamivudine (LAM) and Efavirenz...
AN OVERVIEW OF ELECTRON PROBE MICROANALYSIS
ABSTRACT Electron Probe Microanalysis (EPMA) is an analytical technique that is used to establish the composition of small areas on specimens. It’s one of the several particle-beam techniques These analytical te...