SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF Fe(II) AND Zn(II) IN MULTIVITAMIN SOFT GEL CAPSULE
Journal Title: Int J of Preclin & Pharm Res - Year 2012, Vol 2, Issue 2
Abstract
ABSTRACT The present work describes novel spectrophotometric method for the determination of Fe(II) and Zn(II) in multivitamin soft gel formulation. The method is based on formation of coloured complexes of Fe(II) and Zn(II) with 2,2’- Bipyridyl and Dithizone respectively. Fe(II) forms deep red colored chromogen with 2,2’-Bipyridyl having maximum absorbance at 510nm and Zn(II) complexes with dithizone to develop cherry red color having maximum absorbance at 525nm. Beer’s law was obeyed in the range of 10 – 35 µg/ml for Fe(II) and 2 – 12 µg/ml for Zn(II). The detection limits were 1.85 µg/ml and 0.11 µg/ml for Fe(II) and Zn(II) respectively. The RSD values were, in all instances less than 2.0%. No interference was observed form common pharmaceutical adjuvants and both Fe(II) and Zn(II) were successfully determined in their dosage form. Keywords: Fe(II), Zn(II), Soft Gel Capsule, Dithizone, 2,2’-Bipyridyl.
Authors and Affiliations
Pratik S. Mehta* and Vandana B. Patel#
Keywords
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