PHASE SOLUBILITY STUDY OF HYDROPHOBIC DRUG DOMPERIDONE USING A NOVEL TECHNIQUE INCLUSION COMPLEX WITH β-CYCLODEXTRINE
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 3
Abstract
ABSTRACT An inclusion complex of with a β-cyclodextrine and hydroxy propyl cellulose is a convenient new technique for enhancing the solubility of Domperidone. Phase-solubility studies demonstrated the ability of β- cyclodextrins to complex with Domperidone and increase drug solubility as well as stability also. The solid inclusion was characterized by infrared spectroscopy, differential scanning calorimetry (DSC) and element analysis. These experimental results confirmed the existence of 1:1 inclusion complex of Domperidone with β-cyclodextrin, the formation constant of complex was determined by the Enhancement of dissolution rates with increasing quantity of β-CD in the complex was observed. It was also observed that the complexes exhibit higher dissolution rates than the pure drug and physical mixture. The Apparent stability constant, „K‟ for F 2 and F3 was found to be 142 M-1, 200.3 M-1 respectively, which indicates the formation of stable complex. Keywords: Solubility; Stability, Inclusion Method, β-cyclodextrine Complex.
Authors and Affiliations
D. K. Sanghi and *Rakesh Tiwle
Keywords
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