Difference Spectrophotometric Method Development and Validation For Simultaneous Estimation of Rosuvastatin Calcium and Telmisartan in Bulk and Combined Dosage Form
Journal Title: International Journal of Research in Pharmacy and Science - Year 2012, Vol 2, Issue 2
Abstract
Rosuvastatin calcium and Telmisartan combination is used in the treatment of coronary heartdiseases. UV spectrophptometric and chromatographic methods were reported in the literature forthe estimation of Rosuvastatin calcium and Telmisartan. Therefore a simple and highly sensitivedifference spectrometric method for the estimation of Rosuvastatin calcium and Telmisartan in bulkand in combined dosage form is described. The proposed method is based on the principle that boththe drugs can exhibit two different forms in acidic and basic medium that differs in their absorptionspectra in acidic and basic medium. In the difference spectrum, Rosuvastatin calcium showedmaxima at 248nm and minima at 237.5nm and Telmisartan showed maxima at 309nm and minimaat 286nm. Linearity range was observed in the concentration range of 20-60μg/ml for Rosuvastatincalcium and Telmisartan. Percentage purity and recovery study were in the limit of 98-102% andprecision was less than 2 for both drugs. Limit of Detection for Rosuvastatin calicium andTelmisartan were found to be 0.0635μg/ml and 0.1693μg/ml respectively. Limit of Quantitatin forRosuvastatin calcium and Telmisartan were found to be 0.1925 μg/ml and 0.5129μg/mlrespectively. The proposed method can be successfully used for the analysis of pure drug andmarketed formulation. The method is found to be precise, simple, accurate and can be applied forthe routine estimation of Rosuvastatin calcium and Telmisartan.
Authors and Affiliations
Shah Binal B*
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Difference Spectrophotometric Method Development and Validation For Simultaneous Estimation of Rosuvastatin Calcium and Telmisartan in Bulk and Combined Dosage Form
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