Transdermal Drug Delivery of Salbutamol Sulphate with Different Concentration of Polymers
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 3
Abstract
Matrix-type transdermal therapeutic system containing salbutamol sulphate was prepared using different polymers by solvent evaporation technique. Seven different formulations of transdermal patch composed of hydrophilic and hydrophobic polymers as Hydroxypropyl methyl cellulose (HPMC) and Ethyl cellulose (EC) were prepared respectively. Formulations were carring 0.1 ml of di-methyl sulphoxide as penetration enhancer and 0.2 ml of di-butyl phthalate as plasticizer in 5 ml of chloroform: methanol as casting solvent system in each patch separately. The prepared transdermal patches were evaluated for physio-chemical parameters such as thickness, folding endurance, drug content, percentage moisture absorption, percentage moisture loss, and also evaluated for in vitro release and in vitro permeation rate. The cumulative amount of drug release for seven formulations was found to be 94.589, 76.917, 77.742, 85.101, 87.589, 89.189, 67.16 % respectively. The value for cumulative amount of drug permeated for the said formulations were 95.138, 65.5753, 82.02, 85.1955, 88.297, 90.428, 60.0678 % respectively. On the basis of drug release studies and drug permeation studies formulation F6 emerging as a better formulation than other formulations since it is fulfilling the requirement of better and sustained release for long time (24 hours) which was not possible with HPMC and EC alone which showed maximum % cumulative drug release and maximum permeation rate for short time period.
Authors and Affiliations
Khushbu Ansari, Akhlesh Singhai
Keywords
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