Formulation and Evaluation of Gastroretentive Floating Tablet of Aceclofenac
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 1
Abstract
Tablet can be Utilized for precise delivery of drugs and reduce the drug concentrations at sites other than the target organ. The present study performed by preparation and evaluation of floating tablets of Aceclofenac as model drug. For prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like. hydroxypropyl methylcellulose (HPMC) K 4M, K 15M, psyllium husk, swelling agent as crospovidone and micro crystalline cellulose and gas generating agent like sodium bicarbonate and citric acid and evaluated for floating properties, swelling characteristics and drug release studies. Floating non effervescent tablets were prepared by polypropylene foam powder and different matrix forming polymers like HPMC K 4M, Carbopol 934P xanthan gum and sodium alginate. In vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow both the Higuchi and the Korsemeyer and Peppas equation. The drug release mechanism was found fickian type in most of the formulations. The developed floating tablets of Aceclofenac may be used in clinic for prolonged drug release for at least 24 h, thereby improving the bioavailability and patient compliance.
Authors and Affiliations
Shiv Garg, K Mruthunjaya, Vikram Yadav
Keywords
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