Preparation Of Sustain Release Antipsychotic (Amisulpride) Tablet by Bilayer GRDDS Concept
Journal Title: International Journal of Research in Pharmacy and Science - Year 2012, Vol 2, Issue 4
Abstract
For decades an acute or chronic illness is being clinically treated through delivery of drugs to the patients in form of some pharmaceutical dosage forms,in that one of that is bilayer GRDDS(Gastro Retentive Drug. Delivery system) tablets.in that system those antipsychotic drugs like Amisulpride half-life 11,are retarded in Gastric fluid with the help of different polymers like (Kollidone SR, Cross Povidone) and excipients (Sodium-biCarbonet) which provide the swelling action to the dosage form Because of the swelling action the tablet dissolution will be late so that absorption of the drug will be decreses and duration of action of the drug is increases and sustained. The tablets were prepared by the wet granulation method. Microcrystalline Cellulose, Hydroxy Propyl methylcellulose (HPMC), Talc, Magnesium Stearate, Iso Propyl alcohol, Xanthan Gum, Kollidone, Cross Povidone, Aerosil, Avesil 101, 112, 102, Sodium B i-carbonate, Poly vinyl pyrollidone K-30, Carbopol with varying excipients Six bilayer for mulations AM1-AM6 were prepared by compressing both Instant Release ( IR) and Sustained Release (SR) granules
Authors and Affiliations
Shailesh Sharma, O P Mahatma
Keywords
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