Cardioprotective Effect of ‘Qolest’ a Polyherbal Formulation Against Doxorubicin Induced Cardiotoxicity in Wistar Rats
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 3
Abstract
Albino Wistar rats were used in this study. The activities of serum marker enzymes (CK, CK-MB, LDH, AST, ALT and ALP), lipid profiles such as cholesterol, triglycerides and HDL level were increased significantly in DOX group. In addition, it also exhibited electrocardiographic changes such as reduced R wave and ST segment elevation. Pretreatment with Qolest decreases serum enzyme levels and lipid profiles brought to the near normal values. Pretreatment with Qolest significantly protected the myocardium from the toxic effect of DOX, by increasing the levels of antioxidant enzymes such as GSH, SOD and CAT towards normal and decreased the increased level of malondialdehyde. It also reduced the severity of cellular damage of the myocardium confirmed by histopathology. The restoration of the endogenous antioxidant system clearly depicts that Qolest have produced its protective effect by scavenging the reactive oxygen species (ROS). The results of this study indicated that the cardioprotective effect of Qolest might be attributed to its antioxidant property.
Authors and Affiliations
Manish Shakya, Swaraj Ppatil
Keywords
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