Synthesis & Antimicrobial Activity of 5-Arylidine Derivatives of n-(2-(4-Chlorophenyl)-4-Oxothiazolidin-3-yl) isonicotinamide
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 1
Abstract
5-Arylidine derivatives of N-(2-(4-chlorophenyl)-4-oxothiazolidin-3-yl) isonicotinamide are synthesized using three steps: synthesis of N-(4-chlorobenzylidene isonicotinohydrazide, synthesis of 4- thiazolidinone ring and finally synthesis of 5-benzilidene derivatives. A series of 5-arylidene derivatives of N-(2-(4-chlorophenyl)-4-oxothiazolidin-3-yl) isonicotinamide have been synthesized using different typeS of substituted benzaldehyde and all synthesized compounds were screened for antibacterial and antifungal activities using the turbidimetric method. Turbidity produced is measured by taking absorbance and compared with turbidity produced by standard drug. Ciprofloxacin and clotrimazole were taken as the standard drugs for antibacterial activity and antifungal activity respectively. The compounds were screened against E. Coli, B. Subtilis and S. Aureus for antibacterial activity and against Aspergillus niger, Candida albicans, S.cereviceaes for antifungal activity. Penassay broth and Sabouraud broth medium were used for culturing bacterial and fungal strains respectively. Antibacterial screening revealed that most of the compounds showed activity and MIC was found to be 0.31 µg/ml. Antifungal screening revealed that most of the compounds showed activity and MIC was found to be 0.31 µg/ml aginst Aspergillus niger, Candida albicans and 0.15 µg/ml against S.cereviceaes.
Authors and Affiliations
Vinay Vijay, Naveen Soni, Vinee Khanna
Keywords
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