Spectrophotometric Determination of Guaifenesin and Pseudoephedrine Hydrochloride in Tablet Dosage Form
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 3
Abstract
Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of guaifenesin and pseudoephedrine hydrochloride in tablet dosage form have been developed. First method is simultaneous equation method; in this method 272 nm and 257 nm were selected to measure the absorbance of guaifenesin and pseudoephedrine hydrochloride respectively. The second method is Q‐value analysis based on measurement of absorptivity at 265.50 nm (as an iso‐absorptive point) and 272 nm. guaifenesin and pseudoephedrine hydrochloride at their respective maximum wavelength 272 nm and 257 nm and at isoabsorptive point 265.50 nm shows linearity in a concentration range of 30-150 μg/mL and 300-1500 μg/mL respectively. Recovery studies range from >98.50% for guaifenesin and >98.90% for pseudoephedrine hydrochloride in case of simultaneous equation method and >98.24% for guaifenesin and >98.09% for pseudoephedrine hydrochloride in case of Q‐analysis method confirming the accuracy of the proposed method. The proposed methods are recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific (no heating and no organic solvent extraction is required).
Authors and Affiliations
Rahul Sahu, Hemendra Sharma
Keywords
Related Articles
- EP ID EP150693
- DOI -
- Views 101
- Downloads 0
Pepsin, Papain and Hyaluronidase Enzyme Analysis: A Review
Enzymes are biocatalysts that increase the rate of otherwise slow reactions by decreasing the reactionsactivation energy, without undergoing any net change in their structures at the end of a reaction. Theyare most...
Synthesis, Structural Analysis & Biological Evaluation of Anticonvulsant Activity of Pyrazole Derivatives Containing Thiourea
Compounds were prepared in two steps. First, the chalcones were synthesized by direct condensation of aromatic aldehydes and the substituted acetophenone, using 20% potassium hydroxide in ethanol to form intermediate. Se...
Pharmacognostic and Preliminary Physiochemical Investigations of Thevetia peruviana (Pers.) K. Schum Flowers
Flowers of Plant Thevetia peruviana (Pers.) K. Schum.were reported to possess good medicinal value in traditional system of medicine, the present investigation deals with Macroscopic, Microscopic and preliminary ph...
The Opportunities and Challenges Involved in Registration of Similar Biotherapeutic Products in Emerging Countries
Although global biosimilars market looks attractive and continue to grow, the regulatory and operational hurdles remain in emerging regions. Many emerging nations are establishing biosimilars regulatory pathways, giving...
Isolation, Characterization and Pharmacological Studies of A Flavonol Glucoside From Trichilia connaroides (W.&A.) Bentilizen
A flavonol glucoside, namely populnin (Kaempferol-7-O-glucoside ) was isolated from the leaves of Trichilia connaroides (W.&A.) Bentilizen. Investigation of the methanolic leaf extract of Trichilia connaroides for a...