Spectrophotometric Determination of Guaifenesin and Pseudoephedrine Hydrochloride in Tablet Dosage Form
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 3
Abstract
Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of guaifenesin and pseudoephedrine hydrochloride in tablet dosage form have been developed. First method is simultaneous equation method; in this method 272 nm and 257 nm were selected to measure the absorbance of guaifenesin and pseudoephedrine hydrochloride respectively. The second method is Q‐value analysis based on measurement of absorptivity at 265.50 nm (as an iso‐absorptive point) and 272 nm. guaifenesin and pseudoephedrine hydrochloride at their respective maximum wavelength 272 nm and 257 nm and at isoabsorptive point 265.50 nm shows linearity in a concentration range of 30-150 μg/mL and 300-1500 μg/mL respectively. Recovery studies range from >98.50% for guaifenesin and >98.90% for pseudoephedrine hydrochloride in case of simultaneous equation method and >98.24% for guaifenesin and >98.09% for pseudoephedrine hydrochloride in case of Q‐analysis method confirming the accuracy of the proposed method. The proposed methods are recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific (no heating and no organic solvent extraction is required).
Authors and Affiliations
Rahul Sahu, Hemendra Sharma
Keywords
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