Spectrophotometric Determination of Guaifenesin and Pseudoephedrine Hydrochloride in Tablet Dosage Form
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 3
Abstract
Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of guaifenesin and pseudoephedrine hydrochloride in tablet dosage form have been developed. First method is simultaneous equation method; in this method 272 nm and 257 nm were selected to measure the absorbance of guaifenesin and pseudoephedrine hydrochloride respectively. The second method is Q‐value analysis based on measurement of absorptivity at 265.50 nm (as an iso‐absorptive point) and 272 nm. guaifenesin and pseudoephedrine hydrochloride at their respective maximum wavelength 272 nm and 257 nm and at isoabsorptive point 265.50 nm shows linearity in a concentration range of 30-150 μg/mL and 300-1500 μg/mL respectively. Recovery studies range from >98.50% for guaifenesin and >98.90% for pseudoephedrine hydrochloride in case of simultaneous equation method and >98.24% for guaifenesin and >98.09% for pseudoephedrine hydrochloride in case of Q‐analysis method confirming the accuracy of the proposed method. The proposed methods are recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific (no heating and no organic solvent extraction is required).
Authors and Affiliations
Rahul Sahu, Hemendra Sharma
Keywords
Related Articles
- EP ID EP150693
- DOI -
- Views 118
- Downloads 0
Effect of Adansonia digitata Gum on Some Physicochemical Properties of Paracetamol Pediatric Suspension Formulations
The purpose of this study was to investigate the effect of Adansonia digitata (AD) as a suspendingagent in pharmaceutical formulations using paracetamol as the model drug. Paracetamol pediatric 125mg/5ml suspension...
An Update on Pharmacological Properties of Cumin
Cumin commonly known as Jeera commonly used in the house hold work as spice. Cumin(Cuminum cyminum) is a flowering plant in the family Apiaceae It is an ancient spice which history dates back to use in Egypt used by...
Spectrophotometric Determination of Guaifenesin and Pseudoephedrine Hydrochloride in Tablet Dosage Form
Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of guaifenesin and pseudoephedrine hydrochloride in tablet dosage form have been developed....
Appraisal of Antimicrobial Activity of Malted Psedocereals: Amaranthus cruentus (Amaranth)And Fagopyrum csculentum (Buckwheat)
The aim of this work was to evaluate antibacterial activity of malted extracts of Amaranthus cruentus (Amaranth) and Fagopyrum esculentum (Buckwheat); pseudocereals with plain water and alkali 2% NaHCO3against the eight...
PHYSICOCHEMICAL PROPERTIES, FATTY ACIDS PROFILES AND ANTIOXIDANT PROPERTIES OF SEED OIL OF BREADFRUIT(TRECULIA AFRICANA).
Oil extracted from seed of Treculia Africana (breadfruit) was analyzed for physicochemical properties, free fatty acids profiles and antioxidant properties as part of an on-going screening process for plant constituents...