EFFECT OF ANTI-RETROVIRAL THERAPY (ART) ON HEARING IN HIV POSITIVE PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 41
Abstract
BACKGROUND Not long ago, HIV was an infection which used to be a progressive, advancing and incurable illness with no effective treatment and leading to fast deterioration in health resulting in death. The advent of ART (Anti-Retroviral Treatment) has made a remarkable effect on the management, as HIV/AIDS are living longer and this often means living with ailments that include auditory dysfunction. This study was done to know the effect of ART on hearing in HIV positive patients. OBJECTIVES To study the effect of ART on hearing in HIV positive patients by using Pure Tone and High Frequency Audiometry and OtoAcoustic Emission. STUDY AND DESIGN Longitudinal study with the study population being HIV positive patients registered at ART Centre at K.R. Hospital, Mysore, from Jan 2013 to Jan 2015. MATERIALS AND METHODS Patients with HIV whose CD4 <350 cells/mm3 and newly started with ART were recruited. After a detailed case history and treatment history, a thorough general physical examination was done. Ear examination and Otomicroscopy was carried out. Hearing was assessed using Pure Tone and High Frequency Audiometry up to 12 KHz and Oto-Acoustic Emissions up to 6 KHz at the time of initiation of ART (baseline), 3rd month and 9th month. RESULTS In our study, the patients were in the age group of 25 to 45 years and males constituted 70% and females 30%. Transient Evoked Oto-Acoustic Emissions (Screener), which was done at the time of initiation of ART (Baseline) on all the 40 HIV positive patients had normal OAE’s. During the 3rd and 9th month, OAE’s in the frequency range from 1500 Hz to 6000 Hz were affected in some patients. Hearing assessment using Pure Tone and High Frequency Audiometry up to 12 kHz were done and Mean and Standard Deviation were calculated and the p-values were significant in the frequency range from 3000 Hz to 12000 Hz. CONCLUSION HIV positive patients had abnormal OAE’s in higher frequencies as the duration of ART increases. P-values were significant in higher frequencies with pure tone and high frequency audiometry as the duration of ART increases in HIV positive patients
Authors and Affiliations
Swathi , Satish Raju, Leela , Praveen B. Y, Veenapani , Manjunath
Keywords
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- EP ID EP107196
- DOI 10.14260/jemds/2016/590
- Views 64
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