THE HISTOMORPHOLOGICAL STUDY OF COLORECTAL POLYPS WITH EMPHASIS TO THEIR PROLIFERATIVE ACTIVITY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 93
Abstract
BACKGROUND Colorectal cancer is the second leading cause of cancer deaths worldwide. Most colorectal cancers are believed to arise from benign adenomatous polyps. The risk determination of adenomatous polyps for changing into adenocarcinoma is very important. This study was conducted to assess the various morphological patterns of colorectal polyps and to determine the degree of dysplasia in adenomatous polyps. The objectives of the present study were to determine the location and various histopathological types of colorectal polyps, to assess the degree of dysplasia in adenomatous polyps and to assess the proliferative activity by Ki-67 in various polyps and its relation to grade of dysplasia. MATERIALS AND METHODS A descriptive study was conducted on 65 cases of endoscopically and surgically removed colorectal polyps from patients admitted to gastroenterology and surgery departments, received in the Department of Pathology, Government Medical College, Kottayam during a period of 18 months. Statistical analysis was done with SPSS software. RESULTS Among the 65 cases, 46 patients were males and 19 cases were females. The male-to-female ratio was 2: 1. Majority of patients had complaints of bleeding per rectum. The maximum number of patients were in the age group between 50 to 60 yrs. 41 cases were adenomatous polyps and tubular adenomas were the predominant subtype of adenomatous polyps. Majority of polyps were present on left side of colon. Left-sided polyps show more high-grade dysplasia than right-sided polyps. Polyps with villous architecture have high-grade dysplasia than those of tubular architecture. Pedunculated polyps have more high-grade dysplasia than sessile polyps. No association was found between size of polyp and degree of dysplasia. There was also no association between age of patient and degree of dysplasia. Significant correlation was found between the grade of dysplasia and Ki-67 expression. CONCLUSION Left-sided polyps with villous architecture have more high-grade dysplasia. There was significant correlation between Ki-67 and degree of dysplasia in adenomatous polyps.
Authors and Affiliations
Nisha Gopalan, Laila Raji Navamoni, Sankar Sundaram
Keywords
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- EP ID EP279357
- DOI 10.14260/jemds/2017/1452
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