Effect of fasting on serum lithium levels: An experimental Study in animal models
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 1
Abstract
Muslims throughout the world observe dawn to dusk fast in the month of Holy Ramadan. This study aims to investigate the effect of fasting on serum lithium levels in an animal model under typical conditions of Ramadan. Animals were categorized into oral and intraperitoneal groups. Each group was divided into fasting and non fasting groups along with their controls having six animals each. Mean serum lithium levels of non-fasting and fasting rats were assessed. Mean serum lithium levels of oral non-fasting rats was 0.23±0.004 mequiv/L, (n=6) compared to oral fasting rats 0.20+0.002 mequiv/L, (n=6) mean difference=0.003. The mean difference between mean serum lithium level of intraperitoneal non fasting (0.246+0.015 mequiv/L, n = 6) and intraperitoneal fasting rats (0.206+0.020 mequiv/L, n = 6) was 0.02. These differences were statistically non significant (P>0.05). The mean serum lithium is not grossly affected by fasting in rats under 25ºC and fasting for almost 12 hours which is consistent with a previous clinical study. Lithium can be used by fasting bipolar patients but, will require careful supervision
Authors and Affiliations
Zia Ahmed , Fazal Subhan , Muhammad Tahir Shah3 , Saeed Farooq
Keywords
Related Articles
- EP ID EP88038
- DOI -
- Views 99
- Downloads 0
An approach for enhancing the production of human-like collagen II by enlarging the metabolic flux at pyruvate node
As a key metabolite of glycolysis, Pyruvate affects cell growth and metabolism directly. In order to enhance the production of human-like collagen (HLC) II, pyruvate was added into fermentation broth, and response...
The characteristics of acromegalic patients with hyperprolactinemia and the differences with hyperprolactinemia patients
A substantial proportion of acromegalic patients have co-existent hyperprolactinaemia. To compare this group of population (AC+HPRL) to those of patients with merely hyperprolactinemia (HPRL), a retrospective analy...
Effects of Cistanche deserticola extract on penis erectile response in castrated rats
Cistanche deserticola (CD) has been considered as a tonic agent on reproductive function for thousands of years. The effects of CD extract on penis erectile response were investigated in present study. After castra...
Anti-inflammatory and anti-pyretic properties of Spirulina platensis and Spirulina lonar: A comparative study
Spirulina spp. is a blue-green algae belongs to the family of Oscillatoriaceae, which having diverse biological activity. The aim of this current study was to evaluate and compare the anti-pyretic and anti-inflamma...
Clinical curative effect of Percutaneous vertebroplasty combined with 125I-seed implantation in treating spinal metastatic tumor
This paper selected and studied 15 in-hospital patients to analyze and discuss the clinical curative effect of percutaneous vertebroplasty (PVP) combined with 125I-seed implantation in treating spinal metastatic tu...