Effects of Roystonea Regia (D-004) and Saw Palmetto Lipid Extracts in Men with Symptomatic benign Prostatic Hyperplasia
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 6
Abstract
Background: Benign prostatic hyperplasia (BPH), common among elderly men, often causes lower urinary tract symptoms (LUTS). BPH/LUTS pharmacological therapies include 5-reductase inhibitors, 1-adrenoreceptors blockers and phytotherapies, like saw palmetto (SP) lipid extracts. D-004, a lipid extract of Roystonea regia fruits, reduced experimental prostate hyperplasia in rodents and the International Prostate Symptoms Score (IPSS) as effectively as SP in a pilot trial in men with BPH. Objective: To compare the effects of D-004 and SP in the treatment of men with symptomatic BPH.Methods: Sixty-one patients with moderate BPH were double-blindly randomised to D-004 or SP (320 mg/day both) capsules for 4 months. Decrease on IPSS was the primary efficacy variable. Effects on prostate size, residual volume post-voiding and serum prostate specific antigen (PSA) were secondary outcomes.Results: After 2 months on therapy, D-004 and SP decreased (p<0.05) mean IPSS values by 2.1 units versus baseline (15.8% and 16.0% decreases, respectively). This effect increased at study completion, when IPSS decreased by 4.8 (36.0%) with D-004 and by 4.5 units (34.1%) with SP (p<0.0001 in both cases), without differences between groups. Both treatments did not modify prostate size, residual volume post-voiding.Treatment with SP, not with D-004, increased (p<0.05) serum PSA. Two SP-treated patients withdrew from the study, one due to an adverse experience (hemorrhagic stroke). One D-004- and 2 SP-treated patients experienced adverse experiences. Conclusions: D-004 (320 mg/day) for 4 months was as effective as SP (320 mg/day) for decreasing LUTS in men with moderate BPH, and well tolerated. Further studies should confirm these results.
Authors and Affiliations
Raúl Guzmán, ,
Keywords
Related Articles
- EP ID EP104178
- DOI -
- Views 131
- Downloads 0
[b] Comparative study of spirometric parameters between active tobacco smokers and tobacco non-smokers[/b]
Common antibiotics prescribed for acute respiratory tract infected children in Libya.
Background: Acute respiratory infection is a common disease in children. Most cases were due to upper respiratory tract infection. Early intervention and prompt treatment of acute respiratory infections are the ...
Factors Determining Quality Of Life of Geriatric Patients With HIV/AIDS: A Cross Sectional Study In South India
BACKGROUND: With the effectiveness of highly active antiretroviral therapy (HAART), people with HIV are aging .This number is expected to grow because of the aging of younger cohorts with HIV as well as new infec...
Combination of Angkak (Red Yeast Rice), Red Guava (Psidium guajava Linn) Leaf Extract and Red Guava Fruit J
: Dengue fever leads to decrease in the number of thrombocytes. Objective of this research was to study the effect of combination of angkak (red yeast rice), Psidium guajava fruit juice, and P. guajava leavesextra...
[b] PHARMACOGNOSTICAL & PRILIMINARY PHYTOCHEMICAL STUDY OF HIPTAGE BENGHALENSIS (L) KURZ[/b]