Combination of Angkak (Red Yeast Rice), Red Guava (Psidium guajava Linn) Leaf Extract and Red Guava Fruit J
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 4
Abstract
: Dengue fever leads to decrease in the number of thrombocytes. Objective of this research was to study the effect of combination of angkak (red yeast rice), Psidium guajava fruit juice, and P. guajava leavesextract toward blood hematology profile of the quinine-induced rats (number of thrombocyte, erythrocyte, and hematocrit).Male Sprague-Dawley rats were divided into 6 groups (n=5), consisting of normal group (aquadest), positive control group (Remufit® 0.17 g/kg p.o), negative control group (aquadest), treatment of angkak (400 mg/kg p.o) and P. guajava extract (50 mg/kg p.o) combination, treatment of angkak (400 mg/kg p.o) and P. guajava juice (10 g/kg p.o) combination, and treatment of angkak (400 mg/kg p.o), P. guajava juice (10 g/kg p.o), and P. guajava extract (50 mg/kg p.o) combination. Each group, exclude normal group, was inducedby 100 mg/kg quinine on day 1-14 and were administered by specific treatment for each group until day 28. Observation was done on day 0, 14, and 28.Administration of quinine, angkak, P. guajava juice, and P. guajava leaves ethanol extract showed no affect to body weight of animal models (P>0.05) compared to that of normal group. The highest increase in thrombocyte (up to 127%) was achieved by group that administered with 400 mg/kg bw/day of angkak combined with P. guajava juice 10 g/kg bw/day (P<0.05). Combination of angkak and P. guajava leaves ethanol extract significantly increased erythrocyte number and hematocrit value
Authors and Affiliations
Hasim1 , Dimas Andrianto1 , Aryani Sismin Satyaningtijas2 , and Fitri Rosary3
Keywords
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