EFFICACY OF COMBINATION THERAPY OF METHOTREXATE WITH HYDROXYCHLOROQUINE OR SULFASALAZINE IN RHEUMATOID ARTHRITIS PATIENTS IN KUMAON REGION: A COMPARATIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 51
Abstract
OBJECTIVE To Compare the Efficacy of combination therapy of Methotrexate (MTX) and Hydroxychloroquine (HCQ) with MTX and Sulfasalazine (SSZ) in Rheumatoid Arthritis (RA) patients of Kumaon region. METHODS RA patients of age group in between 18-60 years, a definite rheumatoid arthritis patients based on 2010 ACR/EULAR CRITERIA, presenting to the medicine OPD with Disease Activity Score 28 (DAS 28) Score >3.2 were included in the study, and patients receiving treatment combinations were divided into study groups. In the OPD, HCQ was given at a dosage of 200 mg twice a day, whereas dosage of MTX was 10 to 20 mg/week. The dosage of SSZ was 500 mg to 1000 mg twice a day. The primary end point of the study was based on EULAR DAS 28 response criteria at the end of study period. RESULTS The mean values of DAS 28 score show statistical significant decline within the group in every follow-up and during 2nd and 3rd follow-ups DAS 28 score between 2 groups shows statistical significant difference. At the end of study period (6 months), the difference between 2 study groups was not statistically significant. According to EULAR RESPONSE CRITERIA, good response was seen in 26 patients from group 1st and 27 patients from group 2nd . CONCLUSION The efficacy of drug combinations, i.e. MTX plus SSZ and MTX plus HCQ, in treating Rheumatoid Arthritis patients are comparable. Combination of MTX plus SSZ, however, shows rapid decrease in disease activity as compared to combination of MTX plus HCQ
Authors and Affiliations
Suyash , Bhavana , Paramjeet , Reena , Sanjay
Keywords
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- DOI 10.14260/jemds/2016/765
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