Estimation Of Reference Intervals For Plasma Amylase In Apparently Healthy Adults Of Southern Nigeria
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 9
Abstract
There is need for locally derived age-sex specific laboratory Reference Ranges (RR) for healthy Africans in southern Nigeria. Reference values from American and European population are used for African subjects despite previous studies showing significant differences Our aim was to establish clinical laboratory reference values for plasma amylase that can be used as a baseline for adult patients’ management in southern Nigeria.This study was cross-sectional in design, carried out at the Niger Delta University Teaching Hospital, Okolobiri, Bayelsa State, Southern Nigeria. A total of 200 volunteers, M:F ratio (5.3:4.7) were selected. The exclusion criteria involved those free from chronic diseases like HIV and Hepatitis B. The piccolo express auto analyser assayed for plasma amylase.Reference ranges were constructed using non-parametric method to estimate 2.5 th and 97.5 th as the lower and upper limit respectively. Higher mean male than female values with no significant difference was observed in the reference ranges of plasma amylase. The RR of plasma amylase differed in the older age groups in both sexes. The developed reference values for amylase differed from American values used in our hospital.The differences in RR amongst population, age and sex justifies the need to interpret RR based on age, sex and population. It provides plasma amylase values to be used in southern Nigeria.
Authors and Affiliations
B. E. KASIA , C. G. ORLUWENE
Keywords
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