Evaluation Of Adverse Effects Of Antituberculosis In El-Idrissi Hospital, Kenitra, Morocco
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 1
Abstract
The main obejective of the study is to evaluate the adverse effects of antituberculosis. The present prospective study was conducted from the 2ndof April of year 2012 to the 2ndof April of 2013 with the help of pneumo-phtisiologists in El-idrissi Hospital of Kenitra. It focuses on patients with adverse reactions to treatment with anti-TB.For a period of 12 months, among 515 patients treated against tuberculosis, an occurence of side effects was noticed for 45 cases with an incidence of 8.73%. The sex ratio was 1.36 for males, and the mean average was 37.59 ± 2.72 years.The majority of adverse events was observed in the liver and biliary tract (hepatic cytolysis, cholestasis ...) with a percentage of 27.03%, followed by drug reactions (itching, skin rash ...) with a percentage of 21.62%, and damage to the gastrointestinal system (vomiting, nausea, diarrhea. ...) with a percentage of 16, 22%.The evolution of the patients was positive in 34.8%, however, we observed 4.3% of deaths.The prevalence of adverse reactions to anti-TB remains abnormally high, especially those observed in the liver, in the biliary tract and in the gastrointestinal system.At First, better knowledge of the adverse effects associated with anti-TB, awareness and sensitization of the role of notification of these effects. And second, a closer collaboration between pharmacologists and clinicians concerned with drug control are crucial factors that will contribute in a better quantification and qualification of the adverse effects of antiTB.
Authors and Affiliations
Houda Elkhabbazi , Rajaa Benkirane. ¹Abderrazak Khadmaoui. ²Houda Sefiani. ¹Ali Quyou. ¹Abdelghani Mokhtari. ¹Abdelmajid Soulaymani. ²Rachid
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