Evaluation of antioxidant activities of Cyperusrotundus (Ethanolic extract and purified flavonoid) Against Tetrachloride-Induced Hepatic Damage in Mice
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 1
Abstract
The presence of significant amount of phenolic compounds in the flavonoid purified extract and ethanol extract Cyperusrotundus may account for its high antioxidant activity and exhibit concentration. In this study an interaction was carried out between one dose of CCl4 (3.2 mg/Kg) and the two doses (150 and 300 mg/kg) of ethanolic extract and purifiedCyperusrotundus and one dose of vitamin C (180 mg/kg) were evaluated in mice (in vivo) given injection for 14 days inducting biochemical function SGOT,SGPT and SALP) in liver homogenate, liver function enzymes and histopathological changes of liver. The results showed that tetrachloride carbon declared obvious devastating effects presented by increasing significantly (P<0.05) in concentrations of enzymes SGOT and SGPT and ALP in the blood serum of mice and all of the flavonoids purified and ethanol extract Cyperusrotundus has decreasing significantly (P<0.05) from the increasing in the concentrations of enzymes levels after 14 days of feeding compared to the treatment of carbon tetrachloride. It was noted that there is an increase of uneven concentrations of enzymes in blood compared to the control group indicating that both purified flavonoid and ethanol extract Cyperusrotundus in providing production hepatic damage through these effects or made it within the normal level and repair the damage. If induced liver increased the values of effectiveness of the enzymes of blood in mice are increased after given these substances.
Authors and Affiliations
Essam F. A. Al-Jumaily and Jameelah K. T. Al-Isawi
Keywords
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