Evaluation on bioactivities of total flavonoids from Lavandula angustifolia
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 4
Abstract
Lavandula angustifolia was used to treat flus and fevers, joint swelling and pain in Uighur medicine. This study aimed to investigate antioxidant, antit anti-inflammatory and antalgic noids content (530.1mg/g rutin/g dry extract) with stronger DPPH scavenging abilities and reduciactivities of total flavonoids from Lavandula angustifolia (LTF). Results indicated that LTF possesses the highest total flavong power. Some flavonoids separated from LTF, and their DPPH scavenging abilities as follows: rosmarinic acid (2, near to Vit C) >luteolin (3) >apigenin (4) >luteolin 7-O-β-D-glucoside (5) >apigenin 7-O-β-D-glucoside (6) >luteolin 7-O-β-D-glucuronide (7). LTF significantly decreased malondialdehyde (MDA) level in D-galactose induced aging model compared to the control group (P<0.05), as well as significantly increased plasma superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities (P<0.05). Moreover, 17.4, 34.8 and 69.6 mg/kg doses of LTF were exhibited significant analgesic and anti-inflammatory activities in a dose dependent manner (P<0.05). Cytotoxicity of LTF on Bel-7402 and Hela cell lines were showed by MTT assay also. These results verified traditional usage of this plant and suggested also that LTF is worth developing and studying further.
Authors and Affiliations
Jun Zhao , Fang Xu , Hua Huang , Tengfei Ji , Chenyang Li , Wei Tan , Yan Chen , Long Ma
Keywords
Related Articles
- EP ID EP111535
- DOI -
- Views 81
- Downloads 0
The preparation of the sustained release metformin hydrochloride microcapsules by the Wurster fluidized bed
The main objective of this study was to prepare sustained release metformin hydrochloride microcapsules by the Wurster fluidized bed and to obtain the optimized coating process and formulation. Fine microcapsules w...
Distribution of selenium and cadmium in soil-rice system of selenium-rich area in Hainan, China
Rice, which is the staple food in East Asia, is a source of Selenium (Se) and Cadmium (Cd). The distribution of Se and Cd in soil-rice system is significant to human nutrition and public health. This study is to ex...
Preliminary screening of 44 plant extracts for anti-tyrosinase and antioxidant activities
In order to find new tyrosinase inhibitors and antioxidant materials, we investigated 44 plants, which were evaluated for the anti-tyrosinase and antioxidant activities. The mushroom tyrosinase inhibition assay and...
Weibull statistical analysis of tensile strength of vascular bundle in inner layer of moso bamboo culm in molecular parasitology and vector biology
Bamboo is a radial gradient variation composite material against parasitology and vector biology, but the vascular bundles in inner layer are evenly distributed. The objective is to determine the regular size patte...
Phytochemical analysis of Hibiscus caesius using high performance liquid chromatography coupled with mass spectrometry
Various species in genus Hibiscus are traditionally known for their therapeutic attributes. The present study focused on the phytochemical analysis of a rather unexplored species Hibiscus caesius (H. caesius), usin...