Evaluation the thermodynamic behavior of nonionic polyoxyethylene surfactants against temperature changes
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 2
Abstract
Micellization is the most important property of surface agents. It plays an important role in the manufacture of pharmaceutical products. The surfactants have many applications in industry, agriculture, mining and oil recovery with functional properties as wetting, foaming and emulsifier in pharmaceutical and cosmetic products. The micellization parameters of surfactants help the manufacture of pharmaceutical products to be appropriate and stable. Therefore, in this study, Polyoxyethylene lauryl ether (C12E23), Polyoxyethylene (10) cetyl ether (C16E10) and Polyoxyethylene (20) cetyl ether (C16E20) were chosen as the nonionic surfactants to examine the effect of temperature variation (10-80°C) on the Critical Micelle Concentration (CMC). The measurement of surface tension was done by a Du Nöuys ring method. The value of CMC was obtained from the surface tension vs. surfactant concentration curve. Since the temperature was increased, the CMC initially decreased and then increased for each surfactant because the formation of the hydrogen bond is harder in the high temperatures. The surface tension γCMC for all three surfactant solutions decreased monotonically as the temperature increased. ΔG°m, ΔH°m and ΔS°m as the thermodynamic parameters of micellization, were also estimated and analyzed. The ΔG°m was decreased (10-80°C) if the temperature was increased. The entropy and enthalpy correlation of micellization showed a significant linearity. For C12E23, C16E20 and C16E10, the compensation temperature (Tc) was obtained 309.5, 313.2 and 314.4 K, respectively. The calculated thermodynamic parameters showed that the entropy influenced on the micellization process at lower temperature, but it affected by enthalpy when temperature was increased.
Authors and Affiliations
Hadi Mahmoudi Moghaddam , Gholamreza Dehghannoudeh , Mohammad Zaman Basir
Keywords
Related Articles
- EP ID EP96107
- DOI -
- Views 113
- Downloads 0
Inferring genome-wide interplay landscape between DNA methylation and transcriptional regulation
DNA methylation and transcriptional regulation play important roles in cancer cell development and differentiation processes. Based on the currently available cell line profiling information from the ENCODE Consort...
Screening and optimization of some inorganic salts for the production of ergot alkaloids from Penicillium species using surface culture fermentation process
The present study deals with the production of ergot alkaloids from Penicillium commune and Penicillium citrinum, using surface culture fermentation process. Impact of various inorganic salts was tested on the prod...
Dissolution of ibuprofen from spray dried and spray chilled particles
The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a...
Quantification of glycyrrhizin in anti-stress herbal formulations by validate HPTLC method: A rational paradigm towards quality control of herbals
In the present study an analytical method of high-performance thin-layer chromatography (HPTLC) has been developed for quantification of glycyrrhizin for marketed antistress liquorice root capsules (LRC) and herbal...
Comparative effects of metformin and pioglitazone on lipid profile of rabbits
This is the initial part of study in which the effects of two oral hypoglycemic drugs metformin and pioglitazone were studied on lipid profile of rabbits. White rabbits of both sexes were equally divided in to thre...