Formulation and Evaluation of Aluminum Adjuvanted Combination Vaccine with Reduced Freeze Sensitivity
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 5
Abstract
Objective of present study is to formulate and evaluate freeze thaw resistant combination vaccine comprises of Diphtheria, tetanus, whole cell pertussis, hepatitis B and haemophilus type b conjugate vaccines. Use of surfactants, sugars, polyols and their combinations to protect vaccines from freezing effects was proved. Freeze thaw resistant combination vaccine prepared by adding novel non ionic block copolymer polaxamer. Presence of polaxamer block copolymer exerts resistance from damage caused by freezing and thawing to aluminum adjuvanted vaccine. Polaxamer 407 itself in high concentrations found suitable to reduce freeze sensitivity. Use of high concentrations of polaxamer block copolymer with concentrated formulation helps in making vaccine freeze thaw resistant up to three freeze thaw cycles. Use of high concentration of polaxamer, thermo reversible nature of polaxamer block copolymer and viscosity modification helps in heat stability improvement as well. Concentratedn formulation developed can be easily diluted or re-suspended with suitable diluent to make final vaccine with required concentration for immunization and also reduces polaxamer concentration to suitable level for human parenteral use. Polaxamer block copolymer gives advantage for easy dispersion of vaccine and making uniform suspension post re-suspension.
Authors and Affiliations
Sujana Prasad Chittineni1 *, Satish Chandra Maheshwari2 , Lakshmi Narasu mangamoori3
Keywords
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