Formulation and Evaluation of Aluminum Adjuvanted Combination Vaccine with Reduced Freeze Sensitivity
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 5
Abstract
Objective of present study is to formulate and evaluate freeze thaw resistant combination vaccine comprises of Diphtheria, tetanus, whole cell pertussis, hepatitis B and haemophilus type b conjugate vaccines. Use of surfactants, sugars, polyols and their combinations to protect vaccines from freezing effects was proved. Freeze thaw resistant combination vaccine prepared by adding novel non ionic block copolymer polaxamer. Presence of polaxamer block copolymer exerts resistance from damage caused by freezing and thawing to aluminum adjuvanted vaccine. Polaxamer 407 itself in high concentrations found suitable to reduce freeze sensitivity. Use of high concentrations of polaxamer block copolymer with concentrated formulation helps in making vaccine freeze thaw resistant up to three freeze thaw cycles. Use of high concentration of polaxamer, thermo reversible nature of polaxamer block copolymer and viscosity modification helps in heat stability improvement as well. Concentratedn formulation developed can be easily diluted or re-suspended with suitable diluent to make final vaccine with required concentration for immunization and also reduces polaxamer concentration to suitable level for human parenteral use. Polaxamer block copolymer gives advantage for easy dispersion of vaccine and making uniform suspension post re-suspension.
Authors and Affiliations
Sujana Prasad Chittineni1 *, Satish Chandra Maheshwari2 , Lakshmi Narasu mangamoori3
Keywords
Related Articles
- EP ID EP126475
- DOI -
- Views 90
- Downloads 0
Study of some Pulmonary Function Tests in Children with Sickle Cell Anemia: Correlation with Iron Overload
[b]Background: [/b]Sickle cell disease is hereditary hemoglobinopathy characterized by abnormal hemoglobin production, hemolytic anemia, and intermittent occlusion of small vessels, leading to acute and chronic t...
Prophylactic effect of sodium valproate in traumatic brain injury patients with early post-traumatic seizures
Background: Post traumatic seizures has been described as a particularly heterogeneous condition, specifically because of the heterogeneity associated with TBI Epidemiological studies have found that PTS accounts for 10–...
Factors Favouring Cholelithiasis in North Indian Population
The present study was done on 132 cases those underwent cholecystectomy for benign Gall Bladder disease. Our study concluded that maximum ,58 cases(43.94%) number of cases were in the age group of 41-50 years fol...
Effect of heavy metals on SDH and LDH enzymes activity of Bivalve Lamellidens marginalis…..
Abstract: Enzymes are referred as biological, catalysts which obey certain general rules. . The literature shows investigative lacunae with regard to effects of heavy metals on SDH and LDH activity of aquatic animals esp...
Healthy Progeny through Ayurved
Motherhood is ultimate and cherished desire of every woman. When she achieves it, she feels completeness in her life. A woman has to prepare mentally and physically ahsve jovial pregnancy and less complicated del...