Study on Antirheumatoid Arthritis Activity
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 4
Abstract
In recent years much attention was paid on role of polysaccharides isolated from natural sources. This study was carried out to investigate the effects of polysaccharide extracted from the green seaweed Cladophora indica Marten (Ci-ps) on collagen induced arthritis. To investigate these effects of Ci-ps of 2 varying test doses (test-200mg/kg , test-400mg/kg ) in comparision to standard dexamethasone ( 0.1 mg/kg/day/po) ,assessment of various parameters such as body weight changes, arthritis index, paw volume and haematological parameters were performed. The body weight was fallen for all the arthritis induced groups, but. Ci-ps of Test -400mg/kg treated group had shown steady increase in bwt throughout the study period. Assessment of arthritis score revealed that high dose of Ci-ps extract has shown remarkable reduction in score when compared to arthritic control group. Test-400mg had shown remarkable decrease in paw volume on day 5 7, and 9 respectively. Haematological results revealed that there is a significant reduction in elevated WBC count, CRP & RF values. The study shows that Ci-ps extract (preferentially test-400mg/kg bwt) could effectively ameliorate CIA and significantly suppress the immune response against Collagen. Hence it can be concluded the polysaccharides of this green seaweed has potential antirhuematoid arthritic activity as they had shown promising results in ameliorating the disease associated altered parameters.
Authors and Affiliations
Neelam begum*, Prof . A. Prameela Rani
Keywords
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