Formulation and in vivo evaluation of diclofenac sodium sustained release matrix tablet: Effect of compression force
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
In the present study, Diclofenac Sodium (DS) matrix tablets were prepared by direct compression method under different compression forces (5, 10, 15 and 20 KN), using ethylcellulose as matrix forming material. The produced tablets were characterized on the foundation of satisfactory tablet properties such as hardness, friability, drug content, weight variations and in vitro drug release rate. Differential scanning calorimetry (DSC), Fourier Transform Infrared (FT-IR) spectroscopy and X-ray diffraction have been used to investigate any incompatibilities of the tablet’s ingredients. Additionally, in vivo bioavailability has been investigated on beagle dogs. Data obtained revealed that, upon increasing compression force the in vitro drug release was sustained and the Tmax value was four hours (for formulations compressed at 15 and 20 kN) compared to the conventional voltarine® 50 tablets (Tmax value of 2 hours).
Authors and Affiliations
Ehab Ibrahim Taha , Gamal Abdel Ghany Shazly , Gamaleldin Ibrahim Harisa , Nahla Sedik Barakat , Fouza Kayem Al-Enazi , Ibrahim Mostafa Elbagory
Keywords
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