Formulation and optimization of floating matrix tablets of clarithromycin using simplex lattice design
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 2
Abstract
The purpose of the present study was to prepare floating matrix tablets of clarithromycin employing simplex lattice design. Hydroxypropyl methylcellulose (HPMC) and Ethyl Cellulose (EC) were used as matrix forming agents; sodium bicarbonate and citric acid as effervescence producing agents. Simplex lattice design was used as optimization technique employing three independent formulation variables viz. concentration of HPMC (X1), Citric Acid (X2), EC (X3) whereas floating lag time, t50%, t90%, and MDT (Mean Dissolution Time) were the response (dependent) variables. Seven formulations (F1-F7) were prepared and evaluated for dissolution studies, floating characteristics, weight variation, hardness, thickness, friability.t50% of the formulations was found to be ranging from 317±2.54 to 522±2.39 minutes. The t90% and MDT of the tablets were found to be ranging between 659.65±1.89 to 967.35±1.67 minutes and 527.20±1.22 to 846.78±2.61 minutes respectively. Total floating time of the formulations was more than 12 hours and the drug content was in the range of 98.54±0.46 to 99.92±0.32. The amount of both HPMC and EC were found to play a dominating role in controlling the release of the drug from the formulation whereas ratios of sodium bicarbonate and citric acid were showing significant effect on the floating lag time. The release exponent (n) from Korsmeyer-Peppas model was found to be between 0.62 and 0.75 indicating non-Fickian or anomalous drug release behavior from the formulated floating matrix tablets. Simplex lattice design was reported to be an effective optimization technique for optimizing pharmaceutical formulations against desired responses.
Authors and Affiliations
Inderbir Singh , Vikrant Saini
Keywords
Related Articles
- EP ID EP96106
- DOI -
- Views 99
- Downloads 0
Cardiotonic and vasoconstriction effects of aqueous methanolic extract of Paspalidium flavidum L.
The cardiovascular activity of aqueous methanolic extract of Paspalidium flavidum L. was evaluated on isolated rabbit heart and aorta. Heart rates, force of contraction and perfusion pressure were assessed in the p...
Controlled release matrix tablets of glipizide: Influence of different grades of ethocel and Co-excipient on drug release
The aim of the current study was to formulate and evaluate glipizide controlled release matrix tablets by means of different grades of polymer Ethoceland different co-excipients in order to evaluate their effect on...
Phytochemical, antimicrobial, insecticidal and brine shrimp lethality bioassay of the crude methanolic extract of Ajuga parviflora Benth
Methanolic extract of medicinal herb Ajuga parviflora Benth. was evaluated for phytochemical screening (the plant extract showed the presence of aromatic compounds, carbohydrates, glycosides, tannins, alkaloids, po...
Antibacterial activity of bark extracts of Moringa oleifera Lam. against some selected bacteria
The methanol, chloroform, ethyl acetate and aqueous bark extracts of Moringa oleifera were evaluated for their antibacterial activity against four bacteria viz. Staphylococcus aureus, Citrobacter freundii, Bacillus...
Identification and characterization of endogenous viral elements for the three key schistosomes of humans
Endogenous viral elements (EVEs) are widely distributed throughout eukaryotic genomes, and their evolution and potential function have attracted a lot of interest. Draft genome sequences for Schistosoma mansoni, Sc...