Formulation development and comparative in vitro study of metoprolol tartrate (IR) tablets
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 3
Abstract
The objective of the present work was to develop Immediate Release (IR) tablets of Metoprolol Tartrate (MT) and to compare trial formulations to a reference product. Six formulations (F1-F6) were designed using central composite method and compared to a reference brand (A). Two marketed products (brands B and C) were also evaluated. F1-F6 were prepared with Avicel PH101 (filler), Crospovidone (disintegrant) and Magnesium Stearate (lubricant) by direct compression. Pharmacopoeial and non-pharmacopoeial methods were used to assess their quality. Furthermore, drug profiles were characterized using model dependent and independent (f2) approaches. Brands B and C and F5 and F6 did not qualify the tests for content uniformity. Moreover, brand B did not meet weight variation criteria and brand C did not satisfy requirements for single point dissolution test. Of the trial formulations, F2 failed the test for uniformity in thickness while F4 did not disintegrate within time limit. Only F1 and F3 met all quality parameters and were subjected to accelerated stability testing without significant alterations in their physicochemical characteristics. Based on AIC and r2adjusted values obtained by applying various kinetic models, drug release was determined to most closely follow Hixson-Crowell cube root law. F1 was determined to be the optimized formulation.
Authors and Affiliations
Tazeen Husain , Muhammad Harris Shoaib , Rabia Ismail Yousuf , Madiha Maboos , Madeeha Khan , Lubna Bashir , Shazia Naz
Keywords
Related Articles
- EP ID EP123260
- DOI -
- Views 88
- Downloads 0
Quantitative proteomics analysis for effect of Acanthopanax senticosus extract on Neuroinflammation
Acanthopanax senticosus, a traditional herb commonly found in Northeastern Asia, has been used for treating neurodegenerative diseases. However, the molecular and cellular mechanisms of its effect on neuroinflammat...
The effect of enzyme digestion time on the detection of diatom species
This study is aimed at detecting diatom in lung, liver and kidney tissues using PCR - DHPLC technology after different periods of enzyme digestion to assess the effect of enzyme digestion on the detection of diatom...
The effectiveness of Cognitive Behavioral Therapy (CBT) with general exercises versus general exercises alone in the management of chronic low back pain
To evaluate the effectiveness of Cognitive Behavioural Therapy (CBT) along with General exercises and General exercises alone in chronic low back pain. Total 54 patients with chronic low back pain who fulfilled inc...
Physicochemical properties, in vitro release and skin permeation studies of a topical formulation of standardized pomegranate rind extract
The aim of the present study was to develop a stable formulation containing standardized pomegranate rind extracts (SPRE) for topical use in the treatment of dermal diseases. Ellagic acid (EA) as the major active c...
Anti-microbial screening of endophytic fungi from Hypericum perforatum Linn.
Anti-microbial properties of 21 endophytic fungal strains from Hypericum perforatum Linn. were evaluated against three human pathogens, Staphyloccocus aureus, Escherichia coli and Rhodotorula glutinis, and two phyt...