Functional assignment to Mus musculus endostatin mRNA via computational analysis
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 11
Abstract
Endostatin is an endogenous inhibitor of angiogenesis. It was first found secreted in the media of no-metastasizing mouse cells from a hemangioendothelioma cell line in 1997 and was subsequently found in humans. The sequence of endostatin gene (AC: AF257775) has been downloaded from NCBI database and via Conserved Domain Database (CDD), DNA Motif Searching Database (DMSD), DNA binding-site database predicator, the similar domains, motif, DNA binding-site, has been recognized. The result showed in this sequence important motif includes: EGF_1, CTCK_1, and VWFC_1 and 2FE2S_FER_1. Our result showed in this study a total of 10 domain structures which were similar with endostatin protein sequence has been identified.
Authors and Affiliations
Kheirollah Yari1 , Hassan Rasouli
Keywords
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