Hematological and biochemical alterations in malaria and their correlation with Parasitic Index.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 9
Abstract
Malaria is a major health problem in India with 1.04 million cases reported in 2012 leading to 504 deaths. The clinical spectrum depends on the infecting species, level of parasitemia and the immune status of the host. Malaria pathogenesis is based on extensive changes in hematological and biochemical parameters. The objective of this study was to study the clinical features, hematological and biochemical parameters in malaria patients and correlate them with the parasitic index (PI). Material and methods: We conducted a study on 300 malaria patients. The frequency of various symptoms and signs of malaria caused by various plasmodium species were determined. The degree of anemia, WBC count, platelet count serum bilirubin, liver enzymes and serum creatinine levels were studied and their variation depending on the parasitic index was documented. Results: 197 patients had vivax malaria, 76 patients had falciparum malaria and 27 patients had mixed infection. 171 patients had a PI of less than 2%, 100 patients had PI between 2 to 5%, 23 patients had PI between 5 to 10% and only 6 patients had PI of more than 10%. 72.3% of patients had thrombocytopenia, 46.66% had anaemia, 25% had increased bilirubin 29.66% showed increased liver enzymes and 7.66% had increased creatinine levels. Conclusion: There was a correlation between degree of parasitemia and severity of malaria in majority of cases. Derangements in hematological and biochemical parameters were more frequently seen in patients with higher PI. Hence PI can be used as an indicator by the clinician to know the severity of infection and plan appropriate treatment.
Authors and Affiliations
Dr Yasmeen Khatib, Dr Richa Patel, Dr Karen Sequeira ,Dr Gaurav Agrawal,Dr Nitin Chikhale
Keywords
Related Articles
- EP ID EP148536
- DOI -
- Views 103
- Downloads 0
Safety and Efficacy of Pegylated Interferon alpha-2a and Ribavirin Combination in Treatment of Egyptian Patients with Chronic Hepatitis C Genotype-4
[b]Introduction:[/b] Egypt has the highest hepatitis C virus (HCV) seroprevalence in the world mostly caused by HCV genotype 4. The standard of care for chronic hepatitis C (CHC) is a combination of pegylated interfero...
Mutual Diffusion Studies of Bovine Serum Albumin in Water at Different Concentrations and pH with Laser Beam Deflection Technique
Eventhough the structural studies of protein with various methods is flourishing fast; the application of laser beam deflection sensor to study the diffusion mechanism in Albumin Bovine Serum-Water system is not yet repo...
Effectiveness of intra-articular dexmedetomidine as postoperative analgesia in arthroscopic knee surgery (A comparative study)
ABSTRACT: Background And Objectives: To study the effect of inj.Ropivacaine (0.25%) 2mg/kg with and without Inj.Dexmedetomidine (1-2µg/kg) intraarticularly for postoperative analgesia in arthroscopic knee sur...
Helicobacter Pylori- Factors of Virulence and Persistence: The Ability to Colonise the Human Stomach for Extended Periods Despite Host Immune and Inflammatory Responses.
Helicobacter pylori is perhaps the most prevalent and successful human pathogen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H...
Impact of anthelmintic efficacy of Calotropis procera on tegumental enzymes of the trematode, Gastrothylax indicus
The trematode parasite, Gastrothylax indicus was exposed to ethanolic and aqueous flower extract of Calotropis procera to evaluate the anthelmintic efficacy of the plant. The parasites were incubated in 6.25, 12....