Mutual Diffusion Studies of Bovine Serum Albumin in Water at Different Concentrations and pH with Laser Beam Deflection Technique
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 3
Abstract
Eventhough the structural studies of protein with various methods is flourishing fast; the application of laser beam deflection sensor to study the diffusion mechanism in Albumin Bovine Serum-Water system is not yet reported. Diffusivity of the globular protein Albumin in water is relevant in drug delivery, pharmacology and many medicinal fields. Here we well enforced Laser Beam Deflection technique with a fanned out laser beam from a semiconductor diode laser to study the diffusion mechanism with varying pH, temperature and concentration. Laser beam deflection technique based on Fickian laws of diffusion is proved to be an efficient technique with less investment. Even if there is not a remarkable change in the diffusion in the temperature range from 293 K to 303K, the pH variations alter the diffusion process of protein considerably which signal the structural change of Bovine Serum Albumin from linear to globular.
Authors and Affiliations
Dhanya N P1, Sasikumar P R2
Keywords
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