Hepatic histological alterations and biochemical changes induced by sildenafil overdoses
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 6
Abstract
Sildenafil is used for the treatment of erectile dysfunction and is helping millions of men around the world to achieve and maintain a long lasting erection. Fifty healthy male rabbits (Oryctolagus cuniculus) were used in the present study and exposed daily to sildenafil (0, 1, 3, 6, 9mg/kg) for 5 days per week for 7 weeks to investigate the biochemical changes and alterations in the hepatic tissues induced by this drug overdosing. In comparison with respective control rabbits, sildenafil overdoses elevated significantly (p-value<0.05, ANOVA test) alanine aminotransferase (ALT), aspartate aminotransferase (AST), testosterone, follicular stimulating hormone and total protein, while creatinine and urea were lowered with no significant alteration was observed in uric acid and luteinizing hormone concentration. Also sildenafil provoked hepatocytes nuclear alterations, necrosis, hydropic degeneration, bile duct hyperplasia, Kupffer cells hyperplasia, inflammatory cells infiltration, hepatic vessels congestion and evident partial depletion of glycogen content. The results show that subchronic exposure to sildenafil overdoses exhibits significant biochemical and alterations in the hepatic tissues that might affect the functions of the liver and other vital organs.
Authors and Affiliations
Bashir Mahmoud Jarrar , Mansour Ibrahim Almansour
Keywords
Related Articles
- EP ID EP90362
- DOI -
- Views 79
- Downloads 0
Antimicrobial potentials of different solvent extracted samples from Physalis ixocarpa
The present study investigates the antimicrobial activities of different solvent extracted samples isolated from different parts of Physalis ixocarpa through disc diffusion assay using three different concentration...
Distribution and clinical characteristics of pathogenic bacteria causing catheter-related bloodstream infections
This paper on analysis pathogenic bacterial distribution of central veins Catheter-related Blood-Stream Infection (CRBS) and clinical features of different infection. Ninety-one patients with CRBSI were selected, t...
Protection of ginsenoside Rg1 on central nerve cell damage and the influence on neuron apoptosis
This paper aimed to verify the function of ginsenoside in the repair of peripheral nerve injury through the model of sciatic nerve injury in rat. The method was to prepare the model of SD rat injury of sciatic nerv...
Current trends in treatment of obesity in Karachi and possibilities of cost minimization
Our study finds out drug usage trends in over weight and obese patients without any compelling indications in Karachi, looks for deviations of current practices from evidence based antihypertensive therapeutic guid...
The effects and underlying mechanism of interferon therapy on body weight and body composition
Body weight changes in HCV patients on interferon therapy are well documented. However, the underlying mechanism involved in these changes is poorly understood and rarely reported. The main objectives of this revie...