IN SILICO STUDY OF BOSWELLIA SERRATA ROXB. EX COLEBR: A WILD ETHNOMEDICINAL PLANT FOR THERAPEUTIC PURPOSE
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 2
Abstract
ABSTRACT Boswellia serrata Roxb. ex Colebr. is a deciduous tree in the Burseraceae family. It is native to India and Pakistan. Boswellia serrata is in the same botanical Burseraceae family as the tree from which myrrh is harvested. In India, frankincense from the tree is called "salai guggal". In biomedical arena, computer-aided or in silico design is being utilized to expedite and facilitate hit identification, hit-to-lead selection, optimize the absorption, distribution, metabolism, excretion and toxicity profile and avoid safety issues. There are over a hundred chemical substances that have been derived from plants for use as drugs and medicines. Medicinal plants containing natural and its synthesize chemical compound belonging to two research targets (Mitogen-activated protein kinase for cancer and Thymidine monophosphate kinase for TB) and two successful targets (HIV protease for HIV and Enoyl-ACP reductase for malaria). Beside that ligand library compounds were also examined for druglikeness. Molecular docking studies were carried out with docking programmed. The virtual screening from ligand library point towards the best score and efficient binding of the ligand 2-ethenyl-6-methylhept-5-en-1-yl acetate with two research target and two successful targets from the ligand library included in study. The synthesize chemical compound having best score comparison to the natural chemical compound present in the Boswellia serrata Roxb. ex Colebr wild medicinal plant. Keywords: Medicinal Plants, Mitogen-activated protein kinase, Thymidine monophosphate kinas, HIV protease, Enoyl-ACP reductase, Docking.
Authors and Affiliations
Patel Nikunj B* and Patel Kaushik C
Keywords
Related Articles
- EP ID EP164580
- DOI -
- Views 153
- Downloads 0
DEVELOPMENT AND VALIDATION OF NEW RP-HPLC METHOD FOR PACLITAXEL IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
ABSTRACT A simple, precise, rapid and accurate reverse phase HPLC method has been developed for the determination of Paclitaxel in bulk and its pharmaceutical dosage form. An enable C18G, 250mm, X4.6mm i.d, 5µm p...
ISOLATION AND CHARACTERISATION OF MULTI DRUG RESISTANCE STRAINS FROM SKIN OF COWRANCH WORKERS
ABSTRACT When drug resistance occurs, the drug or combination of drugs loses its ability to block the germ from reproducing. Over time, the treatment can stop working completely. This means the drugs become less...
DIFFERENCE ABSORBANCE SPECTROPHOTOMETRIC DETERMINATION OF OFLOXACIN AND ORNIDAZOLE IN DOSAGE FORM
ABSTRACT Describing the simple, precise and rapid method based on difference absorbance spectroscopic technique for the determination of Ofloxacin (OF) and ornidazole (OZ) in tablet dosage form. The projected met...
DEVELOPMENT AND VALIDATION OF A RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ENALAPRIL MALEATE AND RAMIPRIL IN BULK AND TABLET DOSAGE FORM
ABSTRACT A simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous determination of Enalapril maleate and Ramipril in bulk and tablet dosag...
SIMULTANEOUS ESTIMATION OF EMTRICETABINE, TENOFOVIR DISOPROXIL FUMARATE AND RILPIVIRINE HCL IN TABLET DOSAGE FORMS BY RP-HPLC
ABSTRACT A simple, precise, rapid and accurate RP- HPLC method was developed for the estimation of Emtricetabine (FTC), Tenofovir Disoproxil Fumarate (TDF) and Rilpivirine HCl (RPV)in tablet dosage forms. An Iner...