In-vitro evaluation of timolol maleate matrix tablets formulated with different polymers and ratios
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2014, Vol 4, Issue 3
Abstract
The purpose of the present study was to prepare and characterize twice-daily sustained-release matrix tablets of timolol maleate (TM) using different concentrations of natural, synthetic and semi-synthetic polymers. The effect of nature of the diluents and method of preparation were also studied. Formulations were evaluated for the release of TM over a period of 12 hours using United States Pharmacopoeia (USP) type-II dissolution apparatus. Along with physical properties, the dynamics of water uptake and erosion degree of tablets were also studied. The in-vitro drug release study revealed that the most successful formulation of the study F28 (drug to polymer ratio 1:2) which includes both HPMC K100 and EC (1:1), extended the drug release up to 12 hours, exhibited satisfactory drug release in the initial hours, and the total release pattern was close to the theoretical release profile with similarity factor (f2) above 50. The drug release from optimized formulation (F28) followed first-order kinetics via non-Fickian anomalous) diffusion. FTIR studies revealed that there was no interaction between the drug and excipients. In conclusion, the results indicated that the prepared sustained-release tablets of TM could perform therapeutically better than conventional tablets with improved efficacy and better patient compliance.
Authors and Affiliations
Janakiraman RK , Ramasamy C
Keywords
Related Articles
- EP ID EP107239
- DOI -
- Views 112
- Downloads 0
Toxic effects of acephate in Poecilia sphenops
Toxic effects of Acephate in the tissue of Poecilia sphenops have been reported. The laboratory animal was treated with Acephate, the LC50 was found. The tissues were fixed in formalin for histopathological studies. The...
Identification of De Novo drug candidate for skin cancer using cheminformatics method
Since 2010, skin cancers result in 80,000 deaths a year, 49,000 of which are due to melanoma and 31,000 of which are due to non-melanoma skin cancers. In this paper, we focus on MCR1 protein which acts as a potential tar...
Influence of iaa on in vitro shoot elongation of Eucalyptus tereticornis-103 ; a potencial pulp Wood clone
Paper is an essential commodity required for communication. Literacy pursuits, packaging and a variety of the applications. Wood is the principle source of cellulosic fiber for pulp and paper manufacture. At present, w...
Toxic effects of acephate in Poecilia sphenops
Toxic effects of Acephate in the tissue of Poecilia sphenops have been reported. The laboratory animal was treated with Acephate, the LC50 was found. The tissues were fixed in formalin for histopathological studies. The...
A review on role of medicinal plants on Effective wound healing
Wound healing is a natural body reaction leading to the restoration of structural andfunctional integrity of injured tissues but the rate of healing is slow and microbial infection is high. The increase in resistance tow...