Influence of formulation technique on acrylate methacrylate copolymer modified paracetamol matrix tablets
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
This work was designed to evaluate the influence of various methods such as dry granulation (DG), wet granulation (using the polymer in an ethanolic solution (WGO) or aqueous dispersion (WGA) and solid dispersion (SD) techniques, on properties of paracetamol matrix tablets prepared using varying concentrations of acrylate methacrylate copolymer. Tablet properties were investigated using official and unofficial standards. Drug dissolution profile assessed at pH 1.2 was studied spectrophotometrically at ʎmax of 245 nm. With the use of various kinetic models, the release mechanism of the drug was analyzed. The parameters, maximum amount of drug release (m∞) at time t∞ were obtained, m∞ was ≥ 91.36 %, while t∞ was ≥ 4.5 h. The release rate constant (k) for DG tablets was 15.61 h-1, while, WGO, WGA and SD tablets were 12.90, 11.03 and 10.75 h-1 respectively. The matrix tablets, which exhibited marked retardation in drug release displayed a Higuchi square root of time model (R2 > 0.98). The mechanism through which the drug was released was governed by Fickian diffusion release (n values < 0.5). The performance of the drug was affected by the formulation technique in the order of SD > WGO > WGA > DG.
Authors and Affiliations
Omonyemen Edoise Cash-Torunarigha , Florence Egbomonjiade Eichie , Matthew Ikhuoria Arhewoh
Keywords
Related Articles
- EP ID EP100371
- DOI -
- Views 111
- Downloads 0
Review: An exposition of medicinal preponderance of Moringa oleifera (Lank.)
Abstract: Medicinal plants are believed to be a precious natural reservoir as they are assumed to have paranormal effects for the mankind. Moringa oleifera grows throughout most of the tropics and has numerous indu...
Antidepressant effect and categorization of Inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn
Trigonella foenum- graecum Linn (Fabaceae) is an annual aromatic herb and no wit is cultivated globally like in Pakistan, Egypt, India, Middle East etc. Traditionally it was used in anorexia, as febrifuge, to sooth...
Effects of rocuronium pretreatment on muscle enzyme levels following succinylcholine
Succinylcholine revolutionized anaesthetic practice by providing intense neuromuscular blockade of very rapid onset and ultrashort duration, thereby greatly easing the maneuver of tracheal intubation. However the w...
Central nervous system (CNS) toxicity caused by metal poisoning: Brain as a target organ
People relate the neural disorders with either inheritance or psychological violence but there might be some other reasons responsible for the ailment of people that do not have such a background. The present study...
Immobilization-induced increases of systolic blood pressure and dysregulation of electrolyte balance in ethanol-treated rats
Clinical and experimental studies revealed that alcohol drinking and life event stresses are predisposing factors to hypertension. Intra and extra cellular levels of electrolytes may play important role in the path...