INTRAVITREAL TRIAMCINOLONE IN DIABETIC MACULAR EDEMA:A COMPARATIVE STUDY OF 1MG AND 4MG DOSES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2015, Vol 4, Issue 53
Abstract
Macular edema is a frequent manifestation of diabetic retinopathy and animportant cause of visual disturbance in diabetic patients. [b]AIM: [/b]To compare the efficacy and safety of 1mg and 4mg intravitreal triamcinolone acetonide (IVTA) in the management of diabetic macular edema. [b]SETTING[/b]: Sarojini Devi Eye Hospital, Hyderabad. [b]MATERIAL AND METHODS[/b]: 42 eyes of 42 patients with diabetic macular edema were randomly assigned toreceive either 1-mg or 4-mg dose of Intravitreal triamcinolone acetonide (IVTA). Each patient underwent a complete comprehensive eye examination at baseline andat each visit.Fundus fluorescein angiography and optical coherence angiographywas done at baseline and at 1, 3 and 6 months.BCVA, lens status, IOP wererecorded at each follow up visit. Each patient’s BCVA was measured in snellen’s lines and converted into logarithm of minimum angle of resolution (log MAR) scale for analysis. [b]STATISTICAL ANALYSIS [/b] [b]USED[/b]: The data were statistically evaluated using the Wilcoxon signedrank test, Mann-Whitney test and t tests wherever applicable. A p value of lessthan.05 was considered significant. [b]RESULTS[/b]: There was no statistically significant difference in the mean foveal thickness measurement at baseline (p=.723) or at 3rd month (p=.878) between the sub-groups. BCVA significantly improved from baseline to subsequent visits in both the groups, but there was no statistically significant difference observed in the mean baseline BCVA between the two sub-groups (p=.754). There was no statistically significant difference observed in IOP between the two sub-groups at any follow up visit. [b]CONCLUSIONS[/b]: The results of our study suggest that 1-mg dose of IVTA is as effective as 4-mgdose of IVTA in improving the functional and anatomical outcome in macularedema associated with diabetic retinopathy.
Authors and Affiliations
Sikander Lodhi, Sudhakar Reddy, Santosh Devulapally
Keywords
Related Articles
- EP ID EP148759
- DOI 10.14260/jemds/2015/1336
- Views 91
- Downloads 0
COMPARING MR SPECTROSCOPY WITH COGNITIVE FUSION PROSTATIC BIOPSY IN THE DIAGNOSIS OF CARCINOMA PROSTATE- A PROSPECTIVE DESCRIPTIVE ANALYTIC STUDY
BACKGROUND The current diagnostic approach for prostate cancer- PSA and digital rectal examination followed by transrectal ultrasound biopsies lack both sensitivity and specificity and offer only limited information abou...
EFFECT AND OUTCOME OF HARMFUL TRADITIONAL PRACTICE OF ORAL ADMINISTRATION OF MERCURY IN NEWBORN AND INFANTS
BACKGROUND Oral mercury administration in newborns and infants is being followed as traditional practice in some rural areas around Chidambaram, Tamilnadu. The symptomatology is similar to a systemic illness like septica...
A COMPARATIVE STUDY OF ONDANSETRON VERSUS GRANISETRON IN THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING (PONV) IN DAY CARE GYNAECOLOGICAL LAPAROSCOPIC SURGERIES
BACKGROUND The antiemetic action of 5-hydroxytryptamine receptor antagonists (5HT3 receptor blockers) has been well established. The present study compared the efficacy of the 5HT3 receptor blockers Ondansetron and Grani...
STUDY OF ANTHROPOMETRIC MEASUREMENTS, BIOCHEMICAL PARAMETERS AND HORMONAL LEVELS IN WOMEN WITH PCOS AT A TERTIARY CENTER OF RURAL HARYANA
BACKGROUND During the past decade, our understanding of pathophysiology of PCOS has undergone a remarkable evolution. Despite our familiarity with this disease, some of its fundamental characteristics remains poorly reco...
INTESTINAL PARASITES IN PATIENTS HAVING HAEMATOLOGICAL MALIGNANCIES
BACKGROUND Haematological malignancies like leukaemia, lymphoma and myeloma originate in the bone marrow, lymph nodes which may be acute and chronic. These patients receive immunosuppressive agents, which put t...