Levan as a new additive for colon-specific films: A new approach in the use of exopolysaccharides in time-dependent free films (Aminoalkyl Methacrylate Copolymer RS)
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2013, Vol 26, Issue 5
Abstract
Time-dependent films, augmented with prebiotics, offer potential strategy for colon-specific controlled drug release. In this study, we produced films containing levan (L) and Aminoalkyl Methacrylate Copolymer RS (ER). Free films of ER combined with levan were produced by the casting process and characterized by the mobility of the polymeric matrix, hydration, differential scanning calorimetry (DSC) and thermogravimetry (TGA). The results of this study suggest that the exopolysaccharide levan can be used in combination with ER for colon specific materials. No evidence of incompatibilities between the levan and the synthetic polymer were detected, and levan improved the mobility of the polymeric matrix and the hydrophilicity of the system. Levan may have positively altered the density of the polymeric matrix, as visualized by thermal characterization. The endothermic decomposition peak was shifted with increasing amounts of levan. This new barrier polymer utilized a combination of time-dependent enzymatic mechanisms and can be considered promising for use in the coating of solid oral drugs for specific release.
Authors and Affiliations
Leandro Santos, Edgardo Pineda, Maria Celligoi, Osvaldo Cavalcanti
Keywords
Related Articles
- EP ID EP98841
- DOI -
- Views 99
- Downloads 0
Antipyretic activity of hydro-alcoholic extracts of Moringa oleifera in rabbits
Pyrexia and inflammation are indicatives of various disorders. Modern medicines are available for treatment of pyrexia, but they have few side effects. Several studies are ongoing Worldwide to search natural antipy...
Pharmacognostic studies on Taxus baccata L.: A brilliant source of Anti-cancer agents
The present investigation was undertaken to establish standardization profile of Taxus baccata L. with the help of pharmacognostic parameters, which is not done before. T. baccata (Taxaceae), is native to Europe, i...
Effects of spironolactone towards rabbit atrial remodeling with rapid pacing
This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group...
Antimicrobial potentials and phytochemical analysis of desert cotton (A. Javanica) and flax (L. Ustitatissimum)
The present study reveals antimicrobial potentials and phytochemical analysis of A. javanica and L. ustitatissimum. Phytochemical analysis indicated that the tested plants contained a substantial amount of flavonoi...
Clinical study of ganglioside (GM) combined with methylprednisolone (MP) for early acute spinal injury
This paper aims to make an analysis of the effects of ganglioside (GM) combined with methylprednisolone (MP) in early acute spinal injury. Fifty-three patients with acute spinal cord injury were included in this st...