Ondansetron: A newer aspect of dose response relationship on ileal smooth muscles of rabbit

Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 1

Abstract

 There are several life threatening deadly diseases in our world but ‘Cancer’ out powers them all in recent years. Chemotherapy may be used on its own or an adjunct to other forms of therapy. Despite the advancement in cytotoxic drug therapy and supportive treatment almost 70% of patient suffer from chemotherapy induced nausea and vomiting (CINV). Ondansetron, a 5-HT3 receptor antagonist has now become a gold standard in the treatment of chemotherapy induced nausea and vomiting. The central actions of ondansetron are well established but its peripheral actions are not well recognized. The aim of our study was to explore the peripheral actions of ondansetron. Experiments were performed in five groups (n=6) and ileal smooth muscles activity was recorded on power lab (USA). The effects of increasing concentrations of acetylcholine, serotonin & ondansetron alone was observed in first three groups. In the next two groups effects of acetylcholine and serotonin pretreated with fixed concentration (1ml) of ondansetron (10ˉ⁶ M) were studied. The maximum response obtained by acetylcholine served as a control for our study. Maximum response with acetylcholine was taken as 100% and with serotonin was 177 percent of control. Cumulative dose response curve with ondansetron was triphasic. At 10ˉ⁹M it was 28.8%, whereas with 10ˉ⁸M the amplitude decreased to 16.87%, it reached to plateau at 10ˉ⁶ M. Response of acetylcholine & serotonin was decreased to 57% and 78% respectively in the presence of fixed concentration of ondansetron (10ˉ⁶ M). Ondansetron reduces the acetylcholine and serotonin induced gastrointestinal motility. Our study has indicated that ondansetron apart from having central action also has marked peripheral actions that play an important role in CINV and may act as a partial agonist.

Authors and Affiliations

Ayesha Afzal , Bushra Tayyaba Khan , Salman Bakhtiar

Keywords

Related Articles

 Grape seed and skin extract protects kidney from doxorubicin-induced oxidative injury

 The study investigated the protective effect of grape seed and skin extract (GSSE) against doxorubicininduced renal toxicity in healthy rats. Animals were treated with GSSE or not (control), for 8 days, administere...

 Bacterial susceptibility and resistance analysis of traumatic osteomyelitis

 with the rapid development of industry, agriculture and transportation, the high energy trauma happened accordingly, thus greatly increased the incidence of traumatic osteomyelitis. The clinical traumatic osteomyel...

 In vitro anti-proliferative activities of Aloe perryi flowers extract on human liver, colon, breast, lung, prostate and epithelial cancer cell lines

 Natural products, especially plant extracts have offered vast opportunities in the field of drug development due to its chemical diversity. The genus Aloe has for long been used for medicinal purposes in different...

 Development and validation of a LC–MS/MS method for determination of pinoresinol diglucoside in rat plasma: Application to pharmacokinetic study

Pinoresinol diglucoside (PD), a typical marker compound in Ecommia ulmoides Oliv., is an important and natural antihypertensive drug. A selective, sensitive, and rapid liquid chromatography tandem mass spectrometric (LC-...

 Radical scavenging, antioxidant, and cytotoxic activities of the methanolic extracts from different organs of Ternstroemia pringlei

 Ternstroemia pringlei (Rose) Standl. (Theaceae) is widely used in Mexican traditional medicine to treat a diverse array of illnesses including rheumatoid pains, and is listed as one of the most consumed medicinal p...

Download PDF file
  • EP ID EP90544
  • DOI -
  • Views 100
  • Downloads 0

How To Cite

Ayesha Afzal, Bushra Tayyaba Khan, Salman Bakhtiar (2016).  Ondansetron: A newer aspect of dose response relationship on ileal smooth muscles of rabbit. Pakistan Journal of Pharmaceutical Sciences, 29(1), 114-124. https://europub.co.uk/articles/-A-90544