Optimization of sustained release matrix tablet of metoprolol succinate using central composite design
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2013, Vol 26, Issue 5
Abstract
The present study was performed to optimize the formulation of metoprolol succinate (MS) sustained release tablets using hydroxypropyl methylcellulose (HPMC) and sodium alginate (SA) as the matrix combination. After investigating the effects of various parameters on drug release, a 2-factor, 5-level central composite design was employed, using the amount of HPMC K4M (A) and SA (318 cP) (B) as the independent variables and the drug percentage released at 1h, 4h, 8h, 20h (Q1, Q4, Q8, Q20) as the responses. Response surfaces were established to obtain the matrix ranges and the main factors affecting four responses. In order to validate the optimization study, six confirmatory runs were performed; indicating high predictability of response surface methodology for MS sustained release tablets. Data fitting to Peppas equation indicated that the mechanism of drug release could be diffusion along with erosion. This matrix combination can be used as a good alternative to the commercially pellet technology, which was complicated, time-consuming and energy-intensive.
Authors and Affiliations
Li Li, Huijuan Sun, Tao Jiang, Yuan Gao, Jianjun Zhang
Keywords
Related Articles
- EP ID EP156901
- DOI -
- Views 90
- Downloads 0
The research for the clinical curative effect through combing traditional Chinese medicine with insulin to cure diabetes
The clinical curative effect is observed through curing type 2 diabetes mellitus with the therapy of combing Traditional Chinese Medicine (TCM) with insulin. Method: Both the insulin prescription and the treatment...
Latex agglutination: Diagnose the early cryptococcus neoformans test of capsular polysaccharide antigen
This paper aims to discuss the early diagnosis value of latex agglutination test in Cryptococcal meningitis. The cerebrospinal fluid (CSF) of 112 patients with definite Cryptococcal meningitis and 26 patients with...
Evaluation of MTANNs for eliminating false-positive with different computer aided pulmonary nodules detection software
MTANN (Massive Training Artificial Neural Network) is a promising tool, which applied to eliminate false-positive for thoracic CT in recent years. In order to evaluate whether this method is feasible to eliminate f...
Study of levan productivity from Bacillus subtilis Natto by surface response methodology and its antitumor activity against HepG2 cells using metabolomic approach
Levan productivity of Bacillus subtilis Natto was evaluated in submerged culture varying the pH, temperature and culture time, using factorial design and response surface methodology. The characterization of levan...
Effects of Cistanche deserticola extract on penis erectile response in castrated rats
Cistanche deserticola (CD) has been considered as a tonic agent on reproductive function for thousands of years. The effects of CD extract on penis erectile response were investigated in present study. After castra...