Investigating the in vitro drug release kinetics from controlled release diclofenac potassium-ethocel matrix tablets and the influence of co-excipients on drug release patterns
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2011, Vol 24, Issue 2
Abstract
The objective of the study was to formulate and evaluate controlled release polymeric tablets of Diclofenac Potassium for the release rate, release patterns and the mechanism involved in the release process of the drug. Formulations with different types and grades of Ethyl Cellulose Ether derivatives in several drug-to-polymer ratios (D:P) were compressed into tablets using the direct compression method. In vitro drug release studies were performed in phosphate buffer (pH 7.4) as dissolution medium by using USP Method-1 (Rotating Basket Method). Similarity factor f2 and dissimilarity factor f1 were applied for checking the similarities and dissimilarities of the release profiles of different formulations. For the determination of the release mechanism and drug release kinetics various mathematical / kinetic models were employed. It was found that all of the Ethocel polymers could significantly slow down the drug release rate with Ethocel FP polymers being the most efficient, especially at D:P ratios of 10:03 which lead towards the achievement of zero or near zero order release kinetics
Authors and Affiliations
Shefaat Shah, Kifayat Shah, Asimur Rehman , Gul Khan
Keywords
Related Articles
- EP ID EP160487
- DOI -
- Views 103
- Downloads 0
Comparing the effects of salts of diclofenac and almioprofen with aspirin on serum electrolytes, creatinine and urea levels in rabbits
The effects of diclofenac sodium, diclofenac potassium, alminoprofen and aspirin on serum electrolytes (serum Na+ and K+), urea and creatinine were compared in rabbits in acute and chronic phases of treatment. The data s...
Effect of gonadotrophins, oestradiol and insulin on cumulus expansion of Nili Ravi buffalo oocytes
The objective of the present study was to investigate the cumulus expansions of Nili Ravi buffalo oocytes during cultured in TCM -199 supplemented with 2 µg/ml oestradiol (E2), 0.05 IU/ml recombinant human follicle...
Taguchi’s experimental design for optimizing the production of novel thermostable polypeptide antibiotic from Geobacillus pallidus SAT4
Polypeptide antimicrobials used against topical infections are reported to obtain from mesophilic bacterial species. A thermophilic Geobacillus pallidus SAT4 was isolated from hot climate of Sindh Dessert, Pakistan...
Disintegrants combination: Development and optimization of a cefadroxil fast disintegrating tablet
Fast Disintegrating Tablets (FDTs) is a rapidly growing dosage form preferred for special population (pediatric, geriatric and psychotic patients). It is also developed with the aim of improving bioavailability and...
Approaches to develop PLGA based in situ gelling system with low initial burst
In situ gelling systems have gained much interest owing to their successful application in the preparation of controlled drug delivery and tissue engineering. The commonly used polymer for these systems is the bioc...