PEDIATRIC DOSAGE FORM -CHALLENGE FOR PHARMACEUTICAL INDUSTRY
Journal Title: Int J of Pharm Rev& Res - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT Despite the fact that a significant percentage of the population is unable to swallow tablets and capsules, these dosage forms continue to be the default standard. These oral formulations fail many patients, especially children, because of large tablet or capsule size, poor palatability, and lack of correct dosage strength. The clinical result is often lack of adherence, and therapeutic failure. The lack of an appropriate dosage form limits the use of many medications that may potentially benefit children. While this has been a long-standing problem for pediatric healthcare providers, little attention has been paid to remedying it until recently. This review gives an overview of the limitation of pediatric dosage forms, regulatory aspects for pediatric drug development, challenges in the development of pediatric dosage forms, excipients in the pediatric formulation and their influence on practical and scientific considerations when conducting clinical studies in children. Key words: Pediatric, Regulatory aspects, Palatability, Excipients.
Authors and Affiliations
Pranali VA*, Gangurde AB, Prakruti MA
Keywords
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