Pharmacokinetics of Ecofriendly Meloxicamin Healthy Dogs
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 12
Abstract
Meloxicam has been reported as an eco-friendly alternate of diclofenac sodium which was banned for veterinary use during 2005-06, due to its relay toxicity associated with the catastrophic decline in vulture populations in Indian subcontinent. It is a preferential cyclooxygenase-2 (COX-2) inhibiter with higher therapeutic index as compared to diclofenac, indomethacin and piroxicam. The pharmacokinetics (PK) of a non-steroidal anti-inflammatory drug meloxicam was studied in dogs. Eight dogs used in the experiment were administered @ 0.2 mg.kg-1 body weight as an intravenous (IV) bolus of meloxicam through cephalic vein. Blood samples (3-5mL) were drawn pre medication and then up to 96 hours post-medication. Plasma concentrations of meloxicam were measured in triplicate by HPLC method developed and validated at laboratories of University of Veterinary and Animal Sciences and Lahore College for Women University, Lahore Pakistan. The plasma concentration versus time profile was prepared. Mean ( ± SD) values of pharmacokinetic parameters viz area under curve (AUC), steady state volume of distribution (VDss) , half-life (t1/2), mean residence time (MRT) and clearance (Cl) were 30.93 ± 0.503 μg.h .mL-1, 0.223 ± .001 L .kg-1 ,23.81 ± 0.746 h, 34.29 ± 0.5h and 0.0065 ± 0.003 L.h-1kg.-1 respectively. These parameters of meloxicam in dogs were comparable to the reported values in dogs but different when compared with PK values in many other species like sheep, goats, horses, chicken, rabbits and rats. The pharmacokinetic parameters were put in different PK-equations for calculations of dose. We recommend a single IV dose of 0.2mg .kg-1 body weight of meloxicam in dogs
Authors and Affiliations
Khawaja Tahir Mahmood , Muhammad. Ashraf , Talib Mahmood , Ikram Ul Haq
Keywords
Related Articles
- EP ID EP144887
- DOI -
- Views 102
- Downloads 0
Synthesis and Biological Evaluation Of Some 2-Substituted Derivatives Of Benzimidazoles
A large variety of 2-substituted benzimidazoles have been found to possess anti-inflammatory, antispasmodic, a ntihistaminic, a ntimicrobial, anticancer, c ycloxygenase inhibitor, and HIV-1 reverse transcriptase inhibit...
Rapid Determination of Gemcitabine and Its Metabolite in Human Plasma by LC-MSMS through Micro Protein Precipitation with Minimum Matrix Effect
A novel micro protein precipitation was proposed and employed effectively for bio-sample preparation of only 5 μl of human plasma for rapid liquid chromatography- tandem mass spectrometric (LC-MSMS) determinat...
Formulation and Evaluation of Microparticles of Metronidazole
In the present study it was aimed to formulate delayed release Metronidazole microparticles, which will have enteric as well as sustained release properties. For the preparation of Metronidazole microparticles...
Development and charecterization of PLGA-nanoparticles containing cavedilol
The objective of this study was to prepare PLGA nanoparticles of Carvedilol that will improve the bioavailability of Carvedilol and sustain the release to reduce the initial hypotensive peak and to prolong the...
Evaluation of Anti inflammatory and Analgesic activity of roots of Rubia cordifolia in rats.
The present study was aimed to investigate the analgesic and anti-inflammatory effect of the methanolic extract of root of Rubia cordifolia in rats. Rubia cordifolia (100-300 mg/kg, p.o.) was evaluated for its antiin...