PLANT-MEDIATED SILVER NANOPARTICLES USING Semecarpus anacardium LINN AND BIOLOGICAL EVALUATION OF TOXICOLOGY STUDIES IN ANTI-MUTAGENICITY
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 4
Abstract
ABSTRACT Semecarpus anacardium a common medicinal plant, has multiple uses in traditional system of medicine and in particular it is used as a Vermifuge for centuries. The plant and its extracts have been evaluated for number of activities like antiinflammatory, cardio-tonic, sedative and neuron-muscular. The plant extract was evaluated for Antimutagenicity and mutagenicity studies in order to confirm the safety of its usage. Ethanol extracts of Semecarpus anacardium showed no mutagenicity up to 5 mg/plate when tested with Salmonella typhimurium TA97a, TA98, TA100, TA102 and TA1535 strains with or without metabolic activation. On the other hand ethanol extract of Semecarpus anacardium showed a significant protective effect against mutagenicity induced by mutagen in S. typhimurium TA98 and TA100 strain with or without metabolic activation. The results of these studies indicate that Semecarpus anacardium is non-mutagenic in Ames test, exhibit protection against the mutagenicity induced by 4-nitroquinolene-1-oxide, sodium azide and 2-aminoflourene in TA98 and TA100 strain. Key Words: Semecarpus anacardium; Antimutagenicity; Mutagenicity; Salmonella typhimurium
Authors and Affiliations
1K. Senthil kumar and R. Vasuki
Keywords
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