Protective Effect of Andrographis paniculata Against Atrazine Induced Renotoxicity in Albino Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 10
Abstract
Andrographis paniculata is (AP) a medicinal plant that has been effectively used in traditional Asian medicines for centuries. Its major constituents are diterpenoids, flavonoids and polyphenols. The efficiency of Andrographis paniculata ethanolic extract was studied on atrazine induced renotoxicity in male wistar albino rats. All the oxidative and antioxidative enzymes, malondialdehyde, superoxide dismutase, glutathione peroxidase, catalase, glutathione-s-transferase, reduced glutathione were estimated by standard protocols. Ethanolic extract of AP (150mg/kg bw) was found to protect the rats from renotoxic action of atrazine as evidence by decreased in the level of lipid peroxidation and increased the activities of antioxidant enzymes in the kidney. In addition the ethanolic extract prevented the toxicity of kidney from atrazine exposure. The antioxidant activity of AP suggests it as potential antioxidant against atrazine induced oxidative stress.
Authors and Affiliations
Shirisha K , B . Salma Begum , Mastan M
Keywords
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