redisposing factors of high Lipoprotein(a) in HIV positive patients on HAART at Livingstone General Hospital, Zambia.
Journal Title: Journal of Medical Science and Technology - Year 2015, Vol 4, Issue 2
Abstract
Lipoprotein(a) (Lp(a)) is a highly atherogenic independent risk marker for Cardiovascular disease (CVD). Current studies show that Highly Active antiretroviral Therapy (HAART) raises Lp(a) levels in HIV patients, thereby increasing their risk for CVD. However, data on Lp(a) levels in HIV positive patients on HAART in Zambia is limited. This study was conducted to provide Lp(a) distribution, prevalence of high Lp(a) and the factors associated with high Lp(a) levels in HIV patients on HAART. This cross sectional study was conducted between December 2014 and February 2015 at Livingstone General Hospital laboratory were routine fasting serum samples were collected and sent to the University Teaching Hospital Biochemistry laboratory for Lp(a) determination on Beckman coulter AU480 analyzer. Demographic and clinical data from patient files such as age, gender, ART combination and duration on ART were collected. Data was analyzed using STATA v.12 and Statistical Package for Social Sciences (SPSS) v.17. Sample size was 143 comprising of 57 (39.9%) males and 86(60.1) (%) females who had been on HAART for one to ten years. The study participant’s age ranged from 18-45 years. Cut off value denoting high Lp(a) concentration used in this study was ≥ 30mg/dL. Lp(a) concentration was normally distributed in the study population with mean 24.17mg/dL ±12.47mg/dL. Prevalence of high Lp(a) was 31.5% . Lp(a) was significantly higher with increasing age (p=0.009) and longer duration on HAART (P<0.001) irrespective of specific ART combination (p=0.086), however, those on AZT+3TC+NVP were 9.02 (AOR) (95%CI [1.41,57.54]) times more likely to have high Lp(a) levels compared to the group receiving TDF+FTC+EFV (p=0.020). The prevalence of high Lp(a) in HIV positive patients on HAART at Livingstone General hospital was high. Age, duration on HAART and AZT+3TC+NVP combination were significant predictors of high Lp(a) levels.
Authors and Affiliations
S Masenga, T Kaile
Keywords
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