Regulation of ROS defense system by Hybanthus enneaspermus in CCl4 induce cardiac damage
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 4
Abstract
The purpose of this study is to regulate the ROS (Reactive oxygen species) defense system in cardiac damage induced by CCl4 (Carbon tetra chloride) in rats using Hybanthus enneaspermus. Administration of CCl4 induces damage in the heart of rats as proved by estimation of antioxidant enzymes such as, SOD (Superoxide dismutase), CAT (catalase), GPx (Glutathione Peroxdiase), GR (Glutathione Reductase), GST (Glutathione-S-Transferaes). However, treatment with HEE in CCl4 intoxicated rats was found to be protected the heart, as indicated by the enzyme level in serum. A significant increment of serum enzymes level such as SOD, CAT, GPx, GR and GST were observed following HEE treatment during CCl4 intoxication whereas MDA (Malondialdehyde ) level in HEE treated rats were decreased. The results of our experiment suggest that the treatment of HEE may be the critical remedy for the adverse effect of CCl4 in heart function.
Authors and Affiliations
Anand Thirupathi , Kalaiselvan Ashokan , Shanmugavadivelu Chandra Mohan , Balakumar Rajakrishnan
Keywords
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