Spectrophotometric Estimation of Promethazine Hydrochloride In Bulk and Pharmaceutical Formulations
Journal Title: Int J of Preclin & Pharm Res - Year 2012, Vol 2, Issue 1
Abstract
ABSTRACT Two simple, accurate, rapid and sensitive methods (A and B) have been developed for the estimation of Promethazine Hydrochloride in its pharmaceutical dosage form. The method A and B are based on the formation of chloroform extractable complex of Promethazine Hydrochloride with Bromothymol Blue (method A) and bromocresol green (method B), which shows absorbance maxima at 416 nm and 414 nm respectively. The absorbance-concentration plot is linear over the range of 4- 20 mcg/ml and 2-10 mcg/ml for method A and B respectively. Results of analysis for all the methods were validated statistically and by recovery studies. The proposed methods are economical and sensitive for the estimation of Promethazine Hydrochloride in bulk drug and in its tablet dosage form. Keywords: Ultraviolet-Visible Spectrophotometry, Promethazine Hydrochloride, Bromocresol Green (BCG).
Authors and Affiliations
G. Balammal*, N. S. Midhuna Sagari, B. S. Manoj Kumar, P. Jayachandra Reddy
Keywords
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